Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. (Q36279902)

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12 February 2020

title

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis (English)

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1 reference

1 reference

1

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12 February 2020

Tim West

6

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11

David M Holtzman

1 reference

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2

Rashid Deane

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author name string

Andrew J Gottesdiener

3

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12 February 2020

Philip B Verghese

4

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Floy R Stewart

5

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Andrew C Paoletti

7

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Tristan R Kasper

8

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Ronald B DeMattos

9

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Berislav V Zlokovic

10

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language of work or name

English

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publication date

27 August 2012

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Proceedings of the National Academy of Sciences of the United States of America

12 February 2020

published in

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volume

109

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issue

38

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page(s)

15502-15507

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Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

12 February 2020

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Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

30 September 2017

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

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The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells

30 September 2017

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Apolipoprotein E isoform-specific binding to the low-density lipoprotein receptor

30 September 2017

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ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.

30 September 2017

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Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

30 September 2017

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30 September 2017

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30 September 2017

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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

22 September 2018

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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

22 September 2018

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Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice.

22 September 2018

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The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

22 September 2018

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Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele

22 September 2018

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22 September 2018

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22 September 2018

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Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

22 September 2018

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ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo

22 September 2018

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Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.

22 September 2018

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Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice

22 September 2018

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Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

22 September 2018

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Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22927427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1206446109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927427%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

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12 February 2020

PubMed publication ID

22927427

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927427%20AND%20SRC:MED&resulttype=core&format=json