Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R (Q36284475)

13 August 2017

Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R (English)

1 reference

13 August 2017

Stanley Perlman

3

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author name string

Jingxian Zhao

series ordinal

1

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13 August 2017

Jincun Zhao

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

27 September 2012

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13 August 2017

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13 August 2017

7

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13 August 2017

9

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13 August 2017

e46241

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Creative Commons Attribution 4.0 International

13 August 2017

start time

27 September 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis

30 September 2017

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A role for IL-27 in limiting T regulatory cell populations

30 September 2017

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Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

30 September 2017

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Regulatory T cells exert checks and balances on self tolerance and autoimmunity

30 September 2017

1 reference

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Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

30 September 2017

1 reference

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

30 September 2017

1 reference

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Interleukin 27: a double-edged sword for offense and defense

30 September 2017

1 reference

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control

30 September 2017

1 reference

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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans

30 September 2017

1 reference

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How regulatory T cells work

30 September 2017

1 reference

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

30 September 2017

1 reference

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Regulatory T cells and infection: a dangerous necessity

30 September 2017

1 reference

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

30 September 2017

1 reference

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

30 September 2017

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

30 September 2017

1 reference

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Transforming growth factor-beta induces development of the T(H)17 lineage

30 September 2017

1 reference

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

30 September 2017

1 reference

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Coronavirus infection of the central nervous system: host-virus stand-off

30 September 2017

1 reference

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IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Breach of IL-12 monopoly in the initiation of type 1 immunity to intracellular infections: IL-12 is not required.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

A novel transcription factor, T-bet, directs Th1 lineage commitment

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Stability of the regulatory T cell lineage in vivo.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

IL-27 limits IL-2 production during Th1 differentiation.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459844

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

22 September 2018

1 reference

12 December 2020

Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors

1 reference

12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

12 December 2020

Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cells

1 reference

12 December 2020

IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions

1 reference

12 December 2020

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

12 December 2020

Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells

1 reference

12 December 2020

Regulating Treg cells at sites of inflammation

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0046241

Identifiers

DOI

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13 August 2017

0 references

1 reference

13 August 2017

PubMed publication ID

23029447

1 reference