Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. (Q36297064)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance (English)

1 reference

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20 January 2020

1 reference

2

1 reference

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20 January 2020

author name string

T E Taylor

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

W K Cavenee

series ordinal

3

1 reference

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20 January 2020

publication date

1 March 2012

1 reference

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Current Cancer Drug Targets

20 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

3

1 reference

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20 January 2020

page(s)

197-209

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies

20 January 2020

cites work

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EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction

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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

30 September 2017

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Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

30 September 2017

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Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs.

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Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death

30 September 2017

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Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.

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Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib--a phase II trial

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A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity

30 September 2017

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Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy

30 September 2017

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EGFR tyrosine kinases inhibitors in cancer treatment: in vitro and in vivo evidence.

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Akt and autophagy cooperate to promote survival of drug-resistant glioma

30 September 2017

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DNA damage-mediated induction of a chemoresistant niche

30 September 2017

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Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

30 September 2017

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TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

30 September 2017

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Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

30 September 2017

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Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics

30 September 2017

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Cetuximab insufficiently inhibits glioma cell growth due to persistent EGFR downstream signaling

30 September 2017

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Immunotherapy approaches for malignant glioma from 2007 to 2009.

30 September 2017

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Monoclonal antibodies: versatile platforms for cancer immunotherapy

30 September 2017

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

30 September 2017

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The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor.

30 September 2017

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A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy

30 September 2017

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Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence

30 September 2017

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Clinical applications of a peptide-based vaccine for glioblastoma.

30 September 2017

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An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

30 September 2017

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The PEPvIII-KLH (CDX-110) vaccine in glioblastoma multiforme patients

30 September 2017

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Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: where do we stand?

30 September 2017

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Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization

30 September 2017

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The EGFRvIII variant in glioblastoma multiforme

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

30 September 2017

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An integrated genomic analysis of human glioblastoma multiforme

30 September 2017

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Malignant gliomas in adults

30 September 2017

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Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer

30 September 2017

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Survival of cancer cells is maintained by EGFR independent of its kinase activity

30 September 2017

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Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy

30 September 2017

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Acquired resistance to tyrosine kinase inhibitors during cancer therapy

30 September 2017

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Cetuximab, its clinical use and future perspectives

30 September 2017

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The theoretical basis of cancer-stem-cell-based therapeutics of cancer: can it be put into practice?

30 September 2017

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

30 September 2017

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

30 September 2017

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

30 September 2017

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Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies

30 September 2017

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A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

30 September 2017

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30 September 2017

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A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo

30 September 2017

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30 September 2017

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Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol

30 September 2017

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

30 September 2017

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ERBB receptors and cancer: the complexity of targeted inhibitors

30 September 2017

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30 September 2017

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30 September 2017

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The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours

30 September 2017

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30 September 2017

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30 September 2017

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Development of novel targeted therapies in the treatment of malignant glioma

30 September 2017

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Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme

30 September 2017

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Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

30 September 2017

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Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines

30 September 2017

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Radioimmunotherapy as a novel treatment regimen: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas

30 September 2017

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Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

30 September 2017

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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

30 September 2017

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Targeted molecular therapy of GBM.

30 September 2017

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Inhibition of glioma growth by tumor-specific activation of double-stranded RNA-dependent protein kinase PKR.

30 September 2017

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Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

30 September 2017

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Malignant glioma: genetics and biology of a grave matter.

30 September 2017

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Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials

30 September 2017

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Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications

30 September 2017

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Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma

30 September 2017

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30 September 2017

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Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases

30 September 2017

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Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

30 September 2017

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

30 September 2017

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

30 September 2017

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Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery

30 September 2017

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Autophagy and Akt promote survival in glioma

30 September 2017

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Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes

29 June 2018

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Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.

29 June 2018

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A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors

29 June 2018

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A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis

29 June 2018

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Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas

29 June 2018

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The contemporary role of chemotherapy in the treatment of malignant brain tumor

29 June 2018

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Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Molecular Pathogenesis of Malignant Glial Tumors

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Escape from targeted inhibition: the dark side of kinase inhibitor therapy

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

A Phase II study of anti-epidermal growth factor receptor radioimmunotherapy in the treatment of glioblastoma multiforme

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Suppression of EGFR expression by antisense or small interference RNA inhibits U251 glioma cell growth in vitro and in vivo

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Genetic pathways to glioblastoma: a population-based study

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Down-regulation of Bcl-2 and Bcl-xL expression with bispecific antisense treatment in glioblastoma cell lines induce cell death.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Radioiodinated (I-125) monoclonal antibody 425 in the treatment of high grade glioma patients: ten-year synopsis of a novel treatment.

22 September 2018

1 reference

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Activity of anti-epidermal growth factor receptor monoclonal antibody C225 against glioblastoma multiforme.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

The tumor microenvironment as a determinant of drug response and resistance.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3464093

Localized BCNU chemotherapy and the multimodal management of malignant glioma

22 September 2018

1 reference

12 December 2020

A novel hybrid peptide targeting EGFR-expressing cancers

1 reference

12 December 2020

The Efficacy of Epidermal Growth Factor Receptor-Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and Heterodimerization

1 reference

12 December 2020

Anti-epidermal growth factor receptor monoclonal antibody cetuximab augments radiation effects in glioblastoma multiforme in vitro and in vivo

1 reference

12 December 2020

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

10.2174/156800912799277557

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

22268382

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22268382%20AND%20SRC:MED&resulttype=core&format=json