Measurements of binding thermodynamics in drug discovery (Q36300605)

13 August 2017

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title

Measurements of binding thermodynamics in drug discovery (English)

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13 August 2017

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Geoffrey A Holdgate

1

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PubMed ID

16257377

13 August 2017

Walter H J Ward

series ordinal

2

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13 August 2017

1 November 2005

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13 August 2017

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13 August 2017

10

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13 August 2017

22

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13 August 2017

1543-1550

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Significant discrepancies between van't Hoff and calorimetric enthalpies

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903610-X

7 January 2021

Significant discrepancies between van't Hoff and calorimetric enthalpies. II.

1 reference

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7 January 2021

Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics

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7 January 2021

Significant discrepancies between van't Hoff and calorimetric enthalpies. III

1 reference

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7 January 2021

A thermodynamic study of the binding of linear and cyclic oligosaccharides to the maltodextrin-binding protein of Escherichia coli

1 reference

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7 January 2021

Van't Hoff and calorimetric enthalpies from isothermal titration calorimetry: are there significant discrepancies?

1 reference

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7 January 2021

Calorimetric vs. van't Hoff binding enthalpies from isothermal titration calorimetry: Ba2+-crown ether complexation

1 reference

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7 January 2021

Thermodynamics of protein-ligand interactions: history, presence, and future aspects

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7 January 2021

Volume errors in isothermal titration calorimetry

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7 January 2021

The role of backlash in the "first injection anomaly" in isothermal titration calorimetry

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7 January 2021

A study of statistical error in isothermal titration calorimetry

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7 January 2021

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

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7 January 2021

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

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7 January 2021

The hydrophobic nature of GroEL-substrate binding

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7 January 2021

A predominantly hydrophobic recognition of H-antigenic sugars by winged bean acidic lectin: a thermodynamic study

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7 January 2021

Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase

1 reference

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7 January 2021

The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallographic study

1 reference

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7 January 2021

Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.

1 reference

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7 January 2021

Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics

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7 January 2021

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study

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7 January 2021

Characterization of ligand binding of a soluble human insulin-like growth factor I receptor variant suggests a ligand-induced conformational change

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7 January 2021

Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2

1 reference

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7 January 2021

Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan

1 reference

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7 January 2021

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships

1 reference

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7 January 2021

Titration calorimetric analysis of AcylCoA recognition by myristoylCoA:protein N-myristoyltransferase

1 reference

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7 January 2021

Thermodynamic studies of myristoyl-CoA: protein N-myristoyltransferase using isothermal titration calorimetry.

1 reference

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7 January 2021

Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.

1 reference

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7 January 2021

Coupling of drug protonation to the specific binding of aminoglycosides to the A site of 16 S rRNA: elucidation of the number of drug amino groups involved and their identities

1 reference

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7 January 2021

Thermodynamics of DNA binding and condensation: isothermal titration calorimetry and electrostatic mechanism

1 reference

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7 January 2021

Angströms and calories

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7 January 2021

Can drugs be designed?

1 reference

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7 January 2021

Hydrogen Bonding, Hydrophobic Interactions, and Failure of the Rigid Receptor Hypothesis

1 reference

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7 January 2021

Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding

1 reference

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7 January 2021

Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry

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7 January 2021

Tight ligand binding affinities determined from thermodynamic linkage to temperature by titration calorimetry.

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7 January 2021

Tight binding affinities determined from thermodynamic linkage to protons by titration calorimetry

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7 January 2021

Exact analysis of competition ligand binding by displacement isothermal titration calorimetry.

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7 January 2021

Study of strong to ultratight protein interactions using differential scanning calorimetry

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7 January 2021

4-Chlorobutanol induces unusual reversible and irreversible thermal unfolding of ribonuclease A: thermodynamic, kinetic, and conformational characterization

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7 January 2021

Protein thermal aggregation involves distinct regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin

1 reference

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7 January 2021

Unfolding and aggregation during the thermal denaturation of streptokinase

1 reference

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7 January 2021

Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?

1 reference

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7 January 2021

Salts and glycine increase reversibility and decrease aggregation during thermal unfolding of ribonuclease-A.

1 reference

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7 January 2021

Thermal unfolding of ribonuclease A in phosphate at neutral pH: deviations from the two-state model.

1 reference

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7 January 2021

The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

1 reference

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7 January 2021

Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition

1 reference

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7 January 2021

Thermal and urea-induced unfolding in T7 RNA polymerase: calorimetry, circular dichroism and fluorescence study

1 reference

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7 January 2021

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

1 reference

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7 January 2021

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

1 reference

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7 January 2021

Stabilization of Proteins by Ligand Binding: Application to Drug Screening and Determination of Unfolding Energetics

1 reference

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7 January 2021

High-throughput measurement of protein stability in microtiter plates

1 reference

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7 January 2021

Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors

1 reference

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7 January 2021

High-density miniaturized thermal shift assays as a general strategy for drug discovery

1 reference

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7 January 2021

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery

1 reference

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7 January 2021

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1 reference

7 January 2021

High-throughput biochemistry heats up

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7 January 2021

Calorimetric biosensors with integrated microfluidic channels

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7 January 2021

10.1016/S1359-6446(05)03610-X

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16257377