Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. (Q36315914)

13 August 2017

Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID. (English)

1 reference

13 August 2017

Mani Larijani

1

1 reference

13 August 2017

Alberto Martin

series ordinal

2

1 reference

13 August 2017

language of work or name

English

0 references

publication date

24 September 2007

1 reference

Molecular and Cellular Biology

13 August 2017

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13 August 2017

27

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13 August 2017

23

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13 August 2017

8038-8048

1 reference

describes a project that uses

13 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2169167/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences

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Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

30 September 2017

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Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination

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PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

30 September 2017

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Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

30 September 2017

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The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions

30 September 2017

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

30 September 2017

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The recombination difference between mouse kappa and lambda segments is mediated by a pair-wise regulation mechanism

30 September 2017

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Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops

30 September 2017

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Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

30 September 2017

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Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled

30 September 2017

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

30 September 2017

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Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA

30 September 2017

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Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions

30 September 2017

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The generation of antibody diversity through somatic hypermutation and class switch recombination

30 September 2017

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A Functional Analysis of the Spacer of V(D)J Recombination Signal Sequences

30 September 2017

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

30 September 2017

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AID mediates hypermutation by deaminating single stranded DNA.

30 September 2017

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

30 September 2017

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

30 September 2017

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R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

30 September 2017

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

30 September 2017

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

30 September 2017

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AID and mismatch repair in antibody diversification

30 September 2017

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

30 September 2017

1 reference

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

30 September 2017

1 reference

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

30 September 2017

1 reference

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

30 September 2017

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

30 September 2017

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Transcriptional consequences of topoisomerase inhibition

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Increased transcription levels induce higher mutation rates in a hypermutating cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

One- and three-dimensional pathways for proteins to reach specific DNA sites

30 September 2017

1 reference

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Fidelity of eucaryotic DNA polymerase delta holoenzyme from Schizosaccharomyces pombe

30 September 2017

1 reference

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A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The structure and function of the Eco RI restriction endonuclease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Supercoiling of the DNA template during transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The transcription elongation complex directs activation-induced cytidine deaminase-mediated DNA deamination

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The AID enzyme induces class switch recombination in fibroblasts

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

RNA polymerase II allows unwinding and rewinding of the DNA and thus maintains a constant length of the transcription bubble.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Sequence-specific single-strand-binding protein for the simian virus 40 early promoter stimulates transcription in vitro.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Deoxyuridine is generated preferentially in the nontranscribed strand of DNA from cells expressing activation-induced cytidine deaminase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

An evolutionarily conserved target motif for immunoglobulin class-switch recombination

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

V(D)J Recombination Frequencies Can Be Profoundly Affected by Changes in the Spacer Sequence

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

Recognition of nucleic acid bases and base-pairs by hydrogen bonding to amino acid side-chains

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The cleavage efficiency of the human immunoglobulin heavy chain VH elements by the RAG complex: implications for the immune repertoire

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2169167

The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription

22 September 2018

1 reference

12 December 2020

Direct evidence for the effect of transcription on local DNA supercoiling in vivo

1 reference

12 December 2020

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

12 December 2020

Asymmetric structure of five and six membered DNA hairpin loops

1 reference

12 December 2020

Long-range effects in a supercoiled DNA domain generated by transcription in vitro

1 reference

12 December 2020

DNA deaminases AID and APOBEC3G act processively on single-stranded DNA

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01046-07

1 reference

13 August 2017

1 reference

13 August 2017

1 reference