Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation (Q44486460)

3 December 2017

title

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation (English)

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3 December 2017

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Phuong Pham

1

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3 December 2017

Ronda Bransteitter

series ordinal

2

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3 December 2017

John Petruska

series ordinal

3

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3 December 2017

Myron F Goodman

series ordinal

4

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3 December 2017

language of work or name

English

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publication date

18 June 2003

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3 December 2017

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3 December 2017

volume

424

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3 December 2017

issue

6944

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3 December 2017

page(s)

103-107

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Unique and unprecedented recombination mechanisms in class switching

3 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Somatic hypermutation: how many mechanisms diversify V region sequences?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

RNA editing by base deamination: more enzymes, more targets, new mysteries

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Analyzing fidelity of DNA polymerases.

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

The dynamic nature of the antibody repertoire

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Clusters of point mutations are found exclusively around rearranged antibody variable genes

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Effects of Sequence and Structure on the Hypermutability of Immunoglobulin Genes

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https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Error-prone repair DNA polymerases in prokaryotes and eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

AID and mismatch repair in antibody diversification

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01760

7 January 2021

Identifiers

DOI

10.1038/NATURE01760

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Dimensions Publication ID

3 December 2017

1003846875

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