Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1 (Q36343757)

13 August 2017

Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1 (English)

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13 August 2017

Donatella Trivigno

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13 August 2017

Frank Essmann

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13 August 2017

Stephan M Huber

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13 August 2017

Justine Rudner

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13 August 2017

1 October 2012

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13 August 2017

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13 August 2017

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13 August 2017

893-904

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describes a project that uses

13 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3479835/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

30 September 2017

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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

30 September 2017

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

30 September 2017

1 reference

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

30 September 2017

1 reference

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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

30 September 2017

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The BCL-2 protein family: opposing activities that mediate cell death

30 September 2017

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

30 September 2017

1 reference

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Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

30 September 2017

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The Bcl-2 apoptotic switch in cancer development and therapy

30 September 2017

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

30 September 2017

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Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy

30 September 2017

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BH3-ligand regulates access of MCL-1 to its E3 ligase

30 September 2017

1 reference

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Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.

30 September 2017

1 reference

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Mcl-1 blocks radiation-induced apoptosis and inhibits clonogenic cell death.

30 September 2017

1 reference

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Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.

30 September 2017

1 reference

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

30 September 2017

1 reference

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Bcl-2 expression predicts radiotherapy failure in laryngeal cancer

30 September 2017

1 reference

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

30 September 2017

1 reference

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

30 September 2017

1 reference

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MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

30 September 2017

1 reference

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The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin

30 September 2017

1 reference

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Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

30 September 2017

1 reference

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BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells

30 September 2017

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

30 September 2017

1 reference

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PUMA induces the rapid apoptosis of colorectal cancer cells

30 September 2017

1 reference

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Radiation sensitivity and apoptosis in human lymphoma cells

30 September 2017

1 reference

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

30 September 2017

1 reference

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Contributions of p53 and PMA to gamma-irradiation induced apoptosis in Jurkat cells

30 September 2017

1 reference

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Genetically defining the mechanism of Puma- and Bim-induced apoptosis

30 September 2017

1 reference

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Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1.

29 June 2018

1 reference

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BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

29 June 2018

1 reference

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c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells

29 June 2018

1 reference

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Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis

22 September 2018

1 reference

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Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on celecoxib-induced apoptosis

22 September 2018

1 reference

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Mcl-1 depletion in apoptosis elicited by ionizing radiation in peritoneal resident macrophages of C3H mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3479835

Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23097624

12 December 2020

inferred from PubMed ID database lookup

Notch promotes radioresistance of glioma stem cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23097624

12 December 2020

inferred from PubMed ID database lookup

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23097624

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1593/NEO.12598

1 reference

13 August 2017

1 reference

13 August 2017

1 reference