A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. (Q36367502)

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28 February 2020

title

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease (English)

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28 February 2020

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ChEBI release 2020-05-28

1

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Paul A Clarke

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Rahul S Samant

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Paul Czodrowski

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Elizabeth Fraser

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Florence Raynaud

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Felix Rohdich

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author name string

Christina Esdar

3

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Dennis Waalboer

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Olajumoke Adeniji-Popoola

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Maria-Jesus Ortiz-Ruiz

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Aurélie Mallinger

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Djordje Musil

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Daniel Schwarz

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Klaus Schneider

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Mark Stubbs

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Ken Ewan

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Robert TePoele

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Will Court

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Gary Box

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Melanie Valenti

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Alexis de Haven Brandon

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Sharon Gowan

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Richard Schneider

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Oliver Poeschke

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Andree Blaukat

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Kai Schiemann

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Suzanne A Eccles

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Dirk Wienke

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Julian Blagg

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Paul Workman

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publication date

26 October 2015

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28 February 2020

published in

Nature Chemical Biology

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volume

11

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issue

12

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28 February 2020

page(s)

973-980

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The Mediator complex: a central integrator of transcription

28 February 2020

cites work

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Identifying the proteins to which small-molecule probes and drugs bind in cells

30 September 2017

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A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

30 September 2017

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

30 September 2017

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

30 September 2017

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ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

30 September 2017

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Wnt/beta-catenin signaling in development and disease

30 September 2017

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Regulation of the oxidative stress response through Slt2p-dependent destruction of cyclin C in Saccharomyces cerevisiae

30 September 2017

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

30 September 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

30 September 2017

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Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II

30 September 2017

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Primary Bioassay of Human Tumor Stem Cells

30 September 2017

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Target cells for the cytotoxic effects of carcinogens in the murine small bowel

30 September 2017

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HTS reporter displacement assay for fragment screening and fragment evolution toward leads with optimized binding kinetics, binding selectivity, and thermodynamic signature

28 June 2018

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Roles of cyclin-dependent kinase 8 and β-catenin in the oncogenesis and progression of gastric adenocarcinoma

21 September 2018

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Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis

21 September 2018

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Proteomics strategy for quantitative protein interaction profiling in cell extracts.

21 September 2018

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Mediator is a transducer of Wnt/beta-catenin signaling.

21 September 2018

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21 September 2018

Identifiers

DOI

10.1038/NCHEMBIO.1952

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26502155%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26502155%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

26502155

1 reference