Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements (Q36370959)

13 August 2017

Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements (English)

1 reference

13 August 2017

Klaus Rajewsky

3

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author name string

Philipp Oberdoerffer

series ordinal

1

1 reference

13 August 2017

Tatiana I Novobrantseva

series ordinal

2

1 reference

13 August 2017

language of work or name

English

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publication date

28 April 2003

1 reference

Journal of Experimental Medicine

13 August 2017

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13 August 2017

197

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13 August 2017

9

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13 August 2017

1165-1172

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describes a project that uses

13 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2193966/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes

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The mechanism and regulation of chromosomal V(D)J recombination

30 September 2017

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Monoclonal mice generated by nuclear transfer from mature B and T donor cells

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Autoreactive B cells in the marginal zone that express dual receptors

30 September 2017

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Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement

30 September 2017

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Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

30 September 2017

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B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages

30 September 2017

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Targeting genes for self-excision in the germ line

30 September 2017

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Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

30 September 2017

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Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

30 September 2017

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The lambda B cell repertoire of kappa-deficient mice.

30 September 2017

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Clonal selection and learning in the antibody system

30 September 2017

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Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans

30 September 2017

1 reference

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Receptor editing: an approach by autoreactive B cells to escape tolerance

30 September 2017

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Receptor editing in self-reactive bone marrow B cells

30 September 2017

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B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

30 September 2017

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Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa

30 September 2017

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Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

30 September 2017

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The V(D)J recombination activating gene, RAG-1.

30 September 2017

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Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

30 September 2017

1 reference

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RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

30 September 2017

1 reference

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Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain

30 September 2017

1 reference

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Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription

30 September 2017

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Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice

30 September 2017

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Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

28 June 2018

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A uniform deleting element mediates the loss of kappa genes in human B cells

28 June 2018

1 reference

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Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.

28 June 2018

1 reference

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A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

28 June 2018

1 reference

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Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes

28 June 2018

1 reference

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Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.

21 January 2018

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A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

21 January 2018

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Generation and analysis of interleukin-4 deficient mice

21 January 2018

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A critical role of λ5 protein in B cell development

21 January 2018

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Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

21 January 2018

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Contribution of Receptor Editing to the Antibody Repertoire

21 January 2018

2 references

https://api.crossref.org/works/10.1084%2FJEM.20030402

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/12719477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030402

Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030402

Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20030402

Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors

21 January 2018

1 reference

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The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12719477

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20030402

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

12719477

1 reference