The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering (Q36371248)

13 August 2017

The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering (English)

1 reference

13 August 2017

Adam G Schrum

1

1 reference

PMCID

2194051

13 August 2017

Laurence A Turka

series ordinal

2

1 reference

PMCID

2194051

13 August 2017

language of work or name

English

0 references

publication date

1 September 2002

1 reference

Journal of Experimental Medicine

13 August 2017

1 reference

13 August 2017

196

1 reference

13 August 2017

793-803

1 reference

13 August 2017

6

1 reference

T cell receptor signaling precedes immunological synapse formation

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Cutting edge: antigen-independent CD8 T cell proliferation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The immunological synapse.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

A molecular framework for two-step T cell signaling: Lck Src homology 3 mutations discriminate distinctly regulated lipid raft reorganization events

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Two distinct stages in the transition from naive CD4 T cells to effectors, early antigen-dependent and late cytokine-driven expansion and differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Dynamic interactions of macrophages with T cells during antigen presentation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Dancing the immunological two-step

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The immunological synapse: a molecular machine controlling T cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The central effectors of cell death in the immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Cooperative activation of TCRs by enterotoxin superantigens

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Three-dimensional segregation of supramolecular activation clusters in T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

T cell activation determined by T cell receptor number and tunable thresholds.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Contingent genetic regulatory events in T lymphocyte activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Receptor-stimulated death pathway is opened by antigen in mature T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Evidence for multivalent structure of T-cell antigen receptor complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Determination of CD4 antigen density on cells: role of antibody valency, avidity, clones, and conjugation.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Selection of dual Valpha T cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

T-cell signaling: the importance of receptor clustering

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Modulation of antigen presentation and peptide-MHC-specific, LFA-1-dependent T cell-macrophage adhesion

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

The duration of antigenic stimulation determines the fate of naive and effector T cells.

28 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

A mathematical analysis of TCR serial triggering and down-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194051

IMMUNOLOGY:Dancing the Immunological Two-Step

21 September 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

From TCR Engagement to T Cell Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Expression of two T cell receptor α chains on the surface of normal murine T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Triggering the TCR Complex Causes the Downregulation of Nonengaged Receptors by a Signal Transduction-Dependent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Expression of the T cell antigen receptor zeta chain following activation is controlled at distinct checkpoints. Implications for cell surface receptor down-modulation and re-expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Identification of a Role for NF- B2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity to Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Expression of two T cell receptor alpha chains: dual receptor T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells

21 January 2018

2 references

https://api.crossref.org/works/10.1084%2FJEM.20020158

21 January 2018

12 December 2020

Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

CD8+ T lymphocytes in double alpha beta TCR transgenic mice. II. Competitive fitness of dual alpha beta TCR CD8+ T lymphocytes in the peripheral pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

A stable marker for specific T-cells: a TCR alpha/green fluorescent protein (GFP) fusionprotein reconstitutes a functionally active TCR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

TCR dynamics on the surface of living T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20020158

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

21 January 2018

1 reference

12 December 2020

Functional analysis of the interaction of the antigen-specific T cell receptor with its ligands

1 reference

12 December 2020

Antigen-induced suppression of the proliferative response of T cell clones

1 reference

12 December 2020

Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20020158

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

2194051