Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235 (Q36378398)

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English	Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235	scientific article

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17 February 2020

Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235 (English)

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17 February 2020

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lymphoblastic leukemia

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T-cell acute lymphoblastic leukemia

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glucocorticoid resistance

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inferred from title

2

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17 February 2020

3

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17 February 2020

author name string

Connor P Hall

1

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17 February 2020

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16 June 2015

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17 February 2020

Clinical Cancer Research

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17 February 2020

22

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17 February 2020

621-632

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17 February 2020

3

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17 February 2020

describes a project that uses

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Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration

1 reference

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30 September 2017

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies

1 reference

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30 September 2017

The functions and regulation of the PTEN tumour suppressor

1 reference

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30 September 2017

The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Glucocorticoid resistance in paediatric acute lymphoblastic leukaemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.

1 reference

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30 September 2017

BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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30 September 2017

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

1 reference

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30 September 2017

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group

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30 September 2017

Molecular mechanisms of mTOR-mediated translational control

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30 September 2017

Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide

1 reference

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30 September 2017

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

AKT/PKB signaling: navigating downstream

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681691

30 September 2017

Divergent mechanisms of glucocorticoid resistance in experimental models of pediatric acute lymphoblastic leukemia.

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30 September 2017

A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

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30 September 2017

Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance

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30 September 2017

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

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30 September 2017

Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma

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30 September 2017

Treatment of acute lymphoblastic leukemia

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30 September 2017

Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.

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30 September 2017

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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30 September 2017

The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells

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30 September 2017

Regulation of a distinctive set of genes in glucocorticoid-evoked apoptosis in CEM human lymphoid cells

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30 September 2017

Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis

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Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Synergy, additivism and antagonism in immunosuppression. A critical review

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The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia

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28 June 2018

Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia

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21 September 2018

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

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Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Münster.

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[Corticosteroid-dependent reduction of leukocyte count in blood as a prognostic factor in acute lymphoblastic leukemia in childhood (therapy study ALL-BFM 83)]

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Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26080839

12 December 2020

based on heuristic

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Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26080839

12 December 2020

based on heuristic

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Prednisone therapy of acute lymphatic leukemia in children

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https://pubmed.ncbi.nlm.nih.gov/26080839

12 December 2020

based on heuristic

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Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26080839

12 December 2020

based on heuristic

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Identifiers

10.1158/1078-0432.CCR-15-0114

1 reference

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17 February 2020

1 reference

Europe PubMed Central

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17 February 2020

1 reference

Europe PubMed Central

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17 February 2020

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