Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. (Q37837732)

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22 January 2020

review article

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title

Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways (English)

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22 January 2020

1

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22 January 2020

Massimo Libra

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Danijela Maksimović-Ivanić

22 January 2020

11

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22 January 2020

Sanja Mijatović

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22 January 2020

Giuseppe Montalto

13

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22 January 2020

Ferdinando Nicoletti

8

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ORCID Public Data File 2021

Linda S Steelman

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Linda S Steelman

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C Ruth Kempf

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22 January 2020

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Graziella Malaponte

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22 January 2020

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Alberto M Martelli

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22 January 2020

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Stephen L Abrams

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22 January 2020

4

William H Chappell

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22 January 2020

Lucio Ildebrando Cocco

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Lucio Cocco

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22 January 2020

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Franca Stivala

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22 January 2020

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Melchiorre Cervello

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22 January 2020

author name string

Jörg Bäsecke

10

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22 January 2020

publication date

1 November 2011

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Journal of Cellular Physiology

22 January 2020

number of pages

20

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based on heuristic

inferred from page(s)

published in

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22 January 2020

volume

226

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22 January 2020

issue

11

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22 January 2020

page(s)

2762-2781

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p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

21 January 2018

1 reference

Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells

21 January 2018

1 reference

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

21 January 2018

1 reference

Somatic oncogenic mutations, benign skin lesions and cancer progression: where to look next?

21 January 2018

1 reference

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

21 January 2018

1 reference

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

21 January 2018

1 reference

Post-translational regulation of PTEN.

21 January 2018

1 reference

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

21 January 2018

1 reference

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

21 January 2018

1 reference

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

21 January 2018

1 reference

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

21 January 2018

1 reference

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

21 January 2018

1 reference

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

21 January 2018

1 reference

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

21 January 2018

1 reference

Drug resistance in mutant FLT3-positive AML.

21 January 2018

1 reference

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

21 January 2018

1 reference

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

21 January 2018

1 reference

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

21 January 2018

1 reference

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

21 January 2018

1 reference

MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

21 January 2018

1 reference

SALL4 is a key regulator of survival and apoptosis in human leukemic cells

21 January 2018

1 reference

Regulation of lymphocyte fate by Ras/ERK signals.

21 January 2018

1 reference

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

21 January 2018

1 reference

Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein

21 January 2018

1 reference

Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation

21 January 2018

1 reference

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

21 January 2018

1 reference

Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.

21 January 2018

1 reference

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

21 January 2018

1 reference

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

21 January 2018

1 reference

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

21 January 2018

1 reference

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

21 January 2018

1 reference

Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

21 January 2018

1 reference

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

21 January 2018

1 reference

Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway

21 January 2018

1 reference