Shp2 as a therapeutic target for leptin resistance and obesity (Q36379387)

13 August 2017

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title

Shp2 as a therapeutic target for leptin resistance and obesity (English)

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13 August 2017

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Gen-Sheng Feng

1

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PubMed ID

16441233

13 August 2017

language of work or name

English

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publication date

1 February 2006

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Expert Opinion on Therapeutic Targets

13 August 2017

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13 August 2017

10

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13 August 2017

1

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13 August 2017

135-142

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Modern science versus the stigma of obesity

13 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Leptin and the regulation of body weight in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Obesity wars: molecular progress confronts an expanding epidemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Minireview: nutrient sensing and the regulation of insulin action and energy balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Leptin-replacement therapy for lipodystrophy.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Divergent roles of SHP-2 in ERK activation by leptin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Decreased food intake does not completely account for adiposity reduction after ob protein infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Role of brain insulin receptor in control of body weight and reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Shp-2 positively regulates brain-derived neurotrophic factor-promoted survival of cultured ventral mesencephalic dopaminergic neurons through a brain immunoglobulin-like molecule with tyrosine-based activation motifs/Shp substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Crystal structure of human protein-tyrosine phosphatase SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.1.135

10.1517/14728222.10.1.135

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16441233