Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4. (Q36402572)

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scientific article published in January 2006

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English	Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4.	scientific article published in January 2006

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scholarly article

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

Peptide, peptidomimetic and small-molecule drug discovery targeting HIV-1 host-cell attachment and entry through gp120, gp41, CCR5 and CXCR4. (English)

1 reference

Europe PubMed Central

14 August 2017

1 reference

based on heuristic

inferred from title

author name string

Wieslaw M Kazmierski

1

1 reference

Europe PubMed Central

14 August 2017

Terry P Kenakin

2

1 reference

Europe PubMed Central

14 August 2017

Kristjan S Gudmundsson

3

1 reference

Europe PubMed Central

14 August 2017

language of work or name

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based on heuristic

inferred from title

publication date

1 January 2006

1 reference

Europe PubMed Central

14 August 2017

Chemical Biology and Drug Design

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Europe PubMed Central

14 August 2017

67

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Europe PubMed Central

14 August 2017

1

1 reference

Europe PubMed Central

14 August 2017

13-26

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Europe PubMed Central

14 August 2017

Beyond receptor expression: the influence of receptor conformation, density, and affinity in HIV-1 infection

1 reference

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A spring-loaded mechanism for the conformational change of influenza hemagglutinin

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Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120.

1 reference

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Inhibitors of human immunodeficiency virus type 1 derived from gp41 transmembrane protein: structure--activity studies

1 reference

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Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

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HIV fusion and its inhibition in antiretroviral therapy

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21 January 2018

Core structure of gp41 from the HIV envelope glycoprotein

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Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

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21 January 2018

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 reference

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Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

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21 January 2018

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1 reference

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Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5.

1 reference

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Chemokine receptors - the new frontier for AIDS research.

1 reference

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Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

1 reference

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Low-molecular-weight anti-HIV-1 peptides from the amino-terminal sequence of RANTES: possible lead compounds for coreceptor-directed anti-HIV-1 agents

1 reference

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Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status

1 reference

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21 January 2018

Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140

1 reference

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21 January 2018

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

1 reference

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21 January 2018

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

1 reference

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21 January 2018

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

1 reference

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Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor

1 reference

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HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

1 reference

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21 January 2018

Receptor-mediated endocytosis of CC-chemokines

1 reference

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21 January 2018

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

1 reference

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21 January 2018

PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes

1 reference

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21 January 2018

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

1 reference

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21 January 2018

gp120: Biologic aspects of structural features

1 reference

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21 January 2018

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

1 reference

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21 January 2018

Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor

1 reference

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21 January 2018

Endocytosis and recycling of the HIV coreceptor CCR5

1 reference

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21 January 2018

Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent.

1 reference

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Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

1 reference

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21 January 2018

Endocytosis and recycling of G protein-coupled receptors

1 reference

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Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arrestin 2 in xenopus oocytes

1 reference

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Drug efficacy at G protein-coupled receptors

1 reference

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Modulation of human muscle sodium channels by intracellular fatty acids is dependent on the channel isoform

1 reference

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Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines

1 reference

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HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.

1 reference

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Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity

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Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis

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CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction

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Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains

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HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation

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Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans

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Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

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AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

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Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.

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Involvement of chemokine receptors in breast cancer metastasis

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Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

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A small-molecule inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor

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A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

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Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations

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Design of peptides, proteins, and peptidomimetics in chi space.

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Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.270.5243.1811

Identifiers

10.1111/J.1747-0285.2005.00319.X

1 reference

Europe PubMed Central

14 August 2017

1 reference

Europe PubMed Central

14 August 2017

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