Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists (Q36416335)

14 August 2017

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title

Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists (English)

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14 August 2017

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C A Lunn

1

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14 August 2017

E-P Reich

2

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14 August 2017

J S Fine

3

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14 August 2017

B Lavey

4

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14 August 2017

J A Kozlowski

5

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14 August 2017

R W Hipkin

6

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14 August 2017

D J Lundell

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14 August 2017

L Bober

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14 August 2017

language of work or name

English

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publication date

1 October 2007

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British Journal of Pharmacology

14 August 2017

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14 August 2017

153

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14 August 2017

2

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14 August 2017

226-239

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Macrophages and their products in rheumatoid arthritis

14 August 2017

1 reference

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Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells.

30 September 2017

1 reference

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Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytes

30 September 2017

1 reference

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Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells

30 September 2017

1 reference

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Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25

30 September 2017

1 reference

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Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells

30 September 2017

1 reference

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Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

30 September 2017

1 reference

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30 September 2017

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30 September 2017

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Chemokine inhibition in inflammatory arthritis

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Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells

30 September 2017

1 reference

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CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms.

30 September 2017

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Adenosine A2a receptors induce heterologous desensitization of chemokine receptors

30 September 2017

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Peripheral cannabinoid receptor, CB2, regulates bone mass

30 September 2017

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30 September 2017

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30 September 2017

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Identification and functional characterization of brainstem cannabinoid CB2 receptors

30 September 2017

1 reference

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Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems

30 September 2017

1 reference

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Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice.

30 September 2017

1 reference

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30 September 2017

1 reference

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The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner

30 September 2017

1 reference

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Plastins: versatile modulators of actin organization in (patho)physiological cellular processes

30 September 2017

1 reference

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Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

30 September 2017

1 reference

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Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis

30 September 2017

1 reference

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Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms

30 September 2017

1 reference

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2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells

30 September 2017

1 reference

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14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove

30 September 2017

1 reference

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2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces the migration of EoL-1 human eosinophilic leukemia cells and human peripheral blood eosinophils

30 September 2017

1 reference

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T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis

30 September 2017

1 reference

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A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis

30 September 2017

1 reference

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N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates

30 September 2017

1 reference

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The bicyclam AMD3100 story

30 September 2017

1 reference

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Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation

30 September 2017

1 reference

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Development and evaluation of pharmacological agents targeting chemokine receptors

30 September 2017

1 reference

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Actin cytoskeletal dynamics in T lymphocyte activation and migration

30 September 2017

1 reference

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Interactions between opioid and chemokine receptors: heterologous desensitization

30 September 2017

1 reference

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Targeting monocyte recruitment in CNS autoimmune disease

30 September 2017

1 reference

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The pathogenesis of rheumatoid arthritis: a guide to therapy

30 September 2017

1 reference

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Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol

30 September 2017

1 reference

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The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines

30 September 2017

1 reference

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In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

30 September 2017

1 reference

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Cannabinoids control spasticity and tremor in a multiple sclerosis model

30 September 2017

1 reference

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Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A.

30 September 2017

1 reference

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Suppression of prostate carcinoma cell invasion by expression of antisense L-plastin gene

30 September 2017

1 reference

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Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60

30 September 2017

1 reference

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30 September 2017

1 reference

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Chemoattractant receptor cross-desensitization

30 September 2017

1 reference

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FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils.

30 September 2017

1 reference

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Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells

30 September 2017

1 reference

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Molecular characterization of a peripheral receptor for cannabinoids

30 September 2017

1 reference

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High resolution two-dimensional electrophoresis of proteins

30 September 2017

1 reference

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30 September 2017

1 reference

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28 June 2018

1 reference

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Ca2+-independent protein kinase Cs mediate heterologous desensitization of leukocyte chemokine receptors by opioid receptors

28 June 2018

1 reference

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Activation of the leukocyte plastin gene occurs in most human cancer cells

28 June 2018

1 reference

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FPRL-1 induces modifications of migration-associated proteins in human neutrophils

28 June 2018

1 reference

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Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, [35S]Sch225336.

21 September 2018

1 reference

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Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils

21 September 2018

1 reference

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Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide].

21 September 2018

1 reference

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21 September 2018

1 reference

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Cannabinoid receptor type 2 gene is associated with human osteoporosis.

21 September 2018

1 reference

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Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli.

21 September 2018

1 reference

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Reduced endocannabinoid immune modulation by a common cannabinoid 2 (CB2) receptor gene polymorphism: possible risk for autoimmune disorders

21 September 2018

1 reference

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2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2.

21 September 2018

1 reference

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Evidence for the involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation in mouse ear.

21 September 2018

1 reference

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Effects of cannabinoids on nitric oxide production by chondrocytes and proteoglycan degradation in cartilage

21 September 2018

1 reference

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Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies

21 September 2018

1 reference

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Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

21 September 2018

1 reference

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Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

21 September 2018

1 reference

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Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

21 September 2018

1 reference

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Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide.

21 September 2018

1 reference

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Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model

21 September 2018

1 reference

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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists

21 September 2018

1 reference

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Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor

21 September 2018

1 reference

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Selective Activation of Cannabinoid CB2 Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

Role of cannabinoid CB1 receptors and tumor necrosis factor-alpha in the gut and systemic anti-inflammatory activity of SR 141716 (rimonabant) in rodents

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

Modulation of cytokine responses in Corynebacterium parvum-primed endotoxemic mice by centrally administered cannabinoid ligands

21 September 2018

1 reference

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Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2219522

Influence of disease-modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: Results from a large observational inception study

21 September 2018

1 reference

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Chemotaxis of human peripheral blood eosinophils to 2-arachidonoylglycerol: comparison with other eosinophil chemoattractants

5 December 2018

1 reference

12 December 2020

In vitro and in vivo immunopharmacological profile of Sch 40120

1 reference

12 December 2020

Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies

1 reference

12 December 2020

Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10

1 reference

12 December 2020

Fimbrin in podosomes of monocyte-derived osteoclasts

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12 December 2020

Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis

1 reference

12 December 2020

In vivo and in vitro treatment with the synthetic cannabinoid CP55, 940 decreases the in vitro migration of macrophages in the rat: involvement of both CB1 and CB2 receptors

1 reference

12 December 2020

Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands

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12 December 2020

Temporal variation in CB2R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis

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12 December 2020

Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation

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12 December 2020

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells

1 reference

12 December 2020

Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice

1 reference

12 December 2020

Novel procedure for rapid pharmacokinetic screening of discovery compounds in rats

1 reference

12 December 2020

Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice

1 reference

12 December 2020

Tetrahydrocannabinol-induced suppression of macrophage spreading and phagocytic activity in vitro

1 reference

12 December 2020

Involvement of the cannabinoid CB2 receptor and its endogenous ligand 2-arachidonoylglycerol in oxazolone-induced contact dermatitis in mice

1 reference

12 December 2020

Induction of flare-up reactions in rat antigen-induced arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0707480

1 reference

14 August 2017

1 reference

14 August 2017

1 reference