Bench to bedside: the quest for quality in experimental stroke research (Q36416843)

14 August 2017

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title

Bench to bedside: the quest for quality in experimental stroke research (English)

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14 August 2017

1

Ulrich Dirnagl

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publication date

8 March 2006

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Journal of Cerebral Blood Flow & Metabolism

14 August 2017

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14 August 2017

26

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14 August 2017

12

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14 August 2017

1465-1478

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Transgenic and knockout mice in the study of neurodegenerative diseases

14 August 2017

1 reference

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Recommendations for comprehensive stroke centers: a consensus statement from the Brain Attack Coalition.

21 January 2018

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Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia

21 January 2018

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Emergency medicine animal research: does use of randomization and blinding affect the results?

21 January 2018

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Gene expression changes after focal stroke, traumatic brain and spinal cord injuries

21 January 2018

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Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors

21 January 2018

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Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research

21 January 2018

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Nervous system reorganization following injury

21 January 2018

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Neuroprotection for ischemic stroke: two decades of success and failure

21 January 2018

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Treatment of neural injury with marrow stromal cells

21 January 2018

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Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models.

21 January 2018

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Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationships

21 January 2018

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Why do neuroprotective drugs work in animals but not humans?

21 January 2018

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Clinical trials in acute stroke: why have they not been successful?

21 January 2018

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Thrombolysis: from the experimental findings to the clinical practice

21 January 2018

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Magnetic resonance imaging in experimental models of brain disorders

21 January 2018

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Pathobiology of ischaemic stroke: an integrated view

21 January 2018

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Ischemic tolerance and endogenous neuroprotection

21 January 2018

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Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.

21 January 2018

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Ten year follow-up of a randomised controlled trial of care in a stroke rehabilitation unit

21 January 2018

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The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?

21 January 2018

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21 January 2018

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Prehospital and in-hospital delays in acute stroke care

21 January 2018

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Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis

21 January 2018

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Principles: the need for better experimental design.

21 January 2018

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Design and statistical methods in studies using animal models of development

21 January 2018

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The ischemic penumbra: identification, evolution and treatment concepts

21 January 2018

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Use of animal models has not contributed to development of acute stroke therapies: con.

21 January 2018

1 reference

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Can statistics cause brain damage?

21 January 2018

1 reference

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Models of focal cerebral ischemia in the nonhuman primate

21 January 2018

1 reference

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The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting results.

21 January 2018

1 reference

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Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective

21 January 2018

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Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

21 January 2018

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Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct.

21 January 2018

1 reference

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Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review

21 January 2018

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Calcium antagonists for ischemic stroke: a systematic review

21 January 2018

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Lost in translation: taking neuroprotection from animal models to clinical trials.

21 January 2018

1 reference

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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.

21 January 2018

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Stroke unit treatment. 10-year follow-up

21 January 2018

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Why most published research findings are false

21 January 2018

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Practical aspects of experimental design in animal research

21 January 2018

1 reference

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Does effect of a neuroprotective agent on volume of experimental animal cerebral infarct predict effect of the agent on clinical outcome in human stroke?

21 January 2018

1 reference

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Use of animal models has not contributed to development of acute stroke therapies: pro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JCBFM.9600298

Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.

21 January 2018

1 reference

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The past is the future: innovative designs in acute stroke therapy trials

21 January 2018

1 reference

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Stroke units: the next 10 years

21 January 2018

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Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure

21 January 2018

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Advances in neuroprotection trials

21 January 2018

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Design of future acute-stroke treatment trials

21 January 2018

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What have genetically engineered mice taught us about ischemic injury?

21 January 2018

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Recovery and rehabilitation in stroke: stem cells

21 January 2018

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Mechanisms, challenges and opportunities in stroke

21 January 2018

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Exciting, radical, suicidal: how brain cells die after stroke

21 January 2018

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Surveying the literature from animal experiments: systematic review and meta-analysis are important contributions

21 January 2018

1 reference

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Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

21 January 2018

1 reference

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Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke

21 January 2018

1 reference

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Pooling of animal experimental data reveals influence of study design and publication bias

21 January 2018

1 reference

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21 January 2018

1 reference

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Central nervous system injury-induced immune deficiency syndrome

21 January 2018

1 reference

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Pathophysiology of stroke: lessons from animal models

21 January 2018

1 reference

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The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

21 January 2018

1 reference

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21 January 2018

Publication bias in situ

1 reference

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Using knockout and transgenic mice to study neurophysiology and behavior.

21 January 2018

1 reference

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Where is the evidence that animal research benefits humans?

21 January 2018

1 reference

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Animal models of stroke: do they have value for discovering neuroprotective agents?

21 January 2018

1 reference

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What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?

21 January 2018

1 reference

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Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitation

21 January 2018

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Transplantation for stroke

21 January 2018

1 reference

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Have randomized controlled trials of neuroprotective drugs been underpowered? An illustration of three statistical principles.

21 January 2018

1 reference

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Systematic reviews of animal experiments

21 January 2018

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21 January 2018

Cell therapy for stroke

1 reference

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Cell transplantation for stroke

21 January 2018

1 reference

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Sifting the evidence-what's wrong with significance tests?

21 January 2018

1 reference

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

1 reference

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Recommendations for clinical trial evaluation of acute stroke therapies.

21 January 2018

1 reference

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Empirical assessment of effect of publication bias on meta-analyses.

21 January 2018

1 reference

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Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons

21 January 2018

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Tissue plasminogen activator for acute ischemic stroke

21 January 2018

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Animal models of focal and global cerebral ischemia

21 January 2018

1 reference

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Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia

21 January 2018

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Tackling publication bias in clinical trial reporting. PLoS announces the launch of a new online journal

21 January 2018

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Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approaches

21 January 2018

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21 January 2018

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Mechanisms underlying recovery of motor function after stroke

21 January 2018

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Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review.

21 January 2018

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A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow.

21 January 2018

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Knockout mice: simple solutions to the problems of genetic background and flanking genes

21 January 2018

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Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression

21 January 2018

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Tissue plasminogen activator reduces neurological damage after cerebral embolism.

21 January 2018

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Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia

21 January 2018

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7 January 2021

Epidemiology and reporting of randomised trials published in PubMed journals

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7 January 2021

Publication bias and journals as policemen

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7 January 2021

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7 January 2021

The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findings

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7 January 2021

Effect sizes and p values: what should be reported and what should be replicated?

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7 January 2021

Systematic evaluation and comparison of statistical tests for publication bias

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7 January 2021

Selective reporting biases in cancer prognostic factor studies

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Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks

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For ischemic brain damage, is preclinical evidence of neuroprotection by presynaptic blockade of glutamate release enough?

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7 January 2021

Identifiers

DOI

10.1038/SJ.JCBFM.9600298

1 reference

14 August 2017

1 reference

PubMed ID

16525413