Using knockout and transgenic mice to study neurophysiology and behavior. (Q51990334)

19 April 2018

review article

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title

Using knockout and transgenic mice to study neurophysiology and behavior. (English)

1 reference

19 April 2018

1 reference

M R Picciotto

1

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19 April 2018

K Wickman

series ordinal

2

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19 April 2018

publication date

1 October 1998

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19 April 2018

published in

Physiological Reviews

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19 April 2018

volume

78

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19 April 2018

issue

4

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19 April 2018

page(s)

1131-1163

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19 April 2018

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice

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Structure and function of voltage-gated ion channels

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Transgenesis in rats: technical aspects and models

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Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice

21 January 2018

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Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain

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Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

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Death before birth: clues from gene knockouts and mutations

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Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh

21 January 2018

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Exploratory behavior models of anxiety in mice

21 January 2018

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Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

21 January 2018

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A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

21 January 2018

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Steps towards a mouse model of Alzheimer's disease

21 January 2018

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Reverse genetics of the mouse central nervous system: targeted genetic analysis of neuropeptide function and reverse genetic screens for genes involved in human neurodegenerative disease

21 January 2018

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Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

21 January 2018

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Progress in mapping human epilepsy genes

21 January 2018

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TAXI/UAS: A molecular switch to control expression of genes in vivo

21 January 2018

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

21 January 2018

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An insertional mutation in theBTF3 transcription factor gene leads to an early postimplantation lethality in mice

21 January 2018

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Differences in the liability to self-administer intravenous cocaine between C57BL/6 x SJL and BALB/cByJ mice

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Cystic fibrosis in the mouse by targeted insertional mutagenesis

21 January 2018

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Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression

21 January 2018

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The inward rectifier potassium channel family.

21 January 2018

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Dopamine and opioid regulation of the memory retrieval recovery in mice

21 January 2018

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Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice.

21 January 2018

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Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Ligand-activated site-specific recombination in mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control

21 January 2018

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Superoxide radical and superoxide dismutases

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice

21 January 2018

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Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

21 January 2018

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Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials

21 January 2018

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Organotypic slice cultures: a technique has come of age.

21 January 2018

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Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain

21 January 2018

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

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Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

21 January 2018

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

21 January 2018

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

21 January 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

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The proximal region of the MBP gene promoter is sufficient to induce oligodendroglial-specific expression in transgenic mice.

21 January 2018

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Genetic differences in intravenous cocaine self-administration between C57BL/6J and DBA/2J mice.

21 January 2018

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Synaptic vesicle phosphoproteins and regulation of synaptic function

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

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Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors

21 January 2018

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Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

21 January 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

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Presenilins: genes for life and death

21 January 2018

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Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci

21 January 2018

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Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes

21 January 2018

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Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV-LTR and the tetracycline responsive system

21 January 2018

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Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP

21 January 2018

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The role of the loxP spacer region in P1 site-specific recombination

21 January 2018

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P1 site-specific recombination: nucleotide sequence of the recombining sites

21 January 2018

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Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

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ALS therapy: targets for the future

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Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

21 January 2018

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Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel

21 January 2018

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Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor epsilon 1 subunit.

21 January 2018

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Synaptic vesicles and exocytosis

21 January 2018

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Voltage-gated and inwardly rectifying potassium channels

21 January 2018

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Enhanced LTP in mice deficient in the AMPA receptor GluR2.

21 January 2018

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21 January 2018

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A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

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Impaired synapse elimination during cerebellar development in PKC gamma mutant mice.

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Accumulation of beta-amyloid fibrils in pancreas of transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes

21 January 2018

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

21 January 2018

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Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice

21 January 2018

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Increased startle responses in mice carrying mutations of glycine receptor subunit genes

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells

21 January 2018

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Drugs of abuse: anatomy, pharmacology and function of reward pathways

21 January 2018

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Inducible gene targeting in mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Analysis of behavioral and hippocampal variation in congenic albino and pigmented BALB mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Analysing brain function and dysfunction in transgenic animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Eight-arm maze performance, neophobia, and hippocampal cholinergic alterations after prenatal oxazepam in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The Cyclic AMP Response Element Directs Tyrosine Hydroxylase Expression in Catecholaminergic Central and Peripheral Nervous System Cell Lines from Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Transgenic models of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Studies on the influence of cytosine methylation on DNA recombination and end-joining in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Rational design of an animal model for Alzheimer's disease: introduction of multiple human genomic transgenes to reproduce AD pathology in a rodent

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Animal models for motor neuron diseases: research directions

21 January 2018

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G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

21 January 2018

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https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Synaptic plasticity in the hippocampus: LTP and LTD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Lack of beta-amyloidosis in transgenic mice expressing low levels of familial Alzheimer's disease missense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Tau protein and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Expression of the rat calmodulin gene II in the central nervous system: a 294-base promoter and 68-base leader segment mediates neuron-specific gene expression in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Transgenic approaches to cognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Control of memory formation through regulated expression of a CaMKII transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Assessment of a mutation in the H5 domain of Girk2 as a candidate for the weaver mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

YACs, BACs, PACs and MACs: artificial chromosomes as research tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Giα2 mediates the inhibitory regulation of adenylylcyclase in vivo: Analysis in transgenic mice with Giα2 suppressed by inducible antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Induction of G alpha i2-specific antisense RNA in vivo inhibits neonatal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Neurotrophic and neuroprotective effects of hAPP in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Genetic and molecular advances in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Molecular inactivation. Spatially and temporally defined molecular knockouts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Molecular biology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Huntington disease: new insights into the relationship between CAG expansion and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Nonselective and G betagamma-insensitive weaver K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The genetic basis of neuromuscular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Contrasting properties of two forms of long-term potentiation in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Twelfth Gaddum memorial lecture. Drug receptors and the inhibition of nerve cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Tissue- and site-specific DNA recombination in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Prion diseases and the BSE crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Molar characteristics of exploratory and investigatory behavior in the rat (Rattus norvegicus)

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Short-term synaptic plasticity is altered in mice lacking synapsin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Essential functions of synapsins I and II in synaptic vesicle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Inducible gene expression in mammalian cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Dissociation between components of spatial memory in rats after recovery from the effects of retrohippocampal lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Temporally and spatially regulated somatic mutagenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Excitotoxicity and motor neurone disease: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

An animal model for cystic fibrosis made by gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Glutamate receptor channels: novel properties and new clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Long-term potentiation in mice lacking synapsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The involvement of dopamine in the striatum in passive avoidance training in the chick.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Latency to enter a mirrored chamber: a novel behavioral assay for anxiolytic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Subregion- and cell type-restricted gene knockout in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeted gene disruption: applications in neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeted homologous recombination in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The use of null mutant mice to study complex learning and memory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Abnormal heart rate regulation in GIRK4 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Chronic elevation of S100 beta protein does not alter APP mRNA expression or promote beta-amyloid deposition in the brains of aging transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

The modulation of rat hippocampal synaptic conductances by baclofen and gamma-aminobutyric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Gene targeting constructs: effects of vector topology on co-expression efficiency of positive and negative selectable marker genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Short-term synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

Altered circadian activity rhythms and sleep in mice devoid of prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSREV.1998.78.4.1131

10.1152/PHYSREV.1998.78.4.1131

21 January 2018

Identifiers

DOI

1 reference

19 April 2018

1 reference

19 April 2018