Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. (Q36418940)

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English	Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.	scientific article

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9 March 2020

Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver (English)

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9 March 2020

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Laura Gabriela Sánchez-Lozada

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9 March 2020

Takahiko Nakagawa

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Takahiko Nakagawa

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Richard J. Johnson

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Richard J Johnson

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Miguel A Lanaspa

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Yea-Jin Choi

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Christina Cicerchi

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Mehmet Kanbay

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Carlos A Roncal-Jimenez

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Takuji Ishimoto

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Nanxing Li

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George Marek

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Murat Duranay

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George Schreiner

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9 March 2020

Bernardo Rodriguez-Iturbe

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9 March 2020

Duk-Hee Kang

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3 October 2012

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9 March 2020

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13

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Journal of Biological Chemistry

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287

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9 March 2020

40732-40744

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48

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9 March 2020

Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey

1 reference

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30 September 2017

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease.

1 reference

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30 September 2017

A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake

1 reference

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30 September 2017

Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Serum uric Acid as a predictor for the development of nonalcoholic Fatty liver disease in apparently healthy subjects: a 5-year retrospective cohort study

1 reference

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30 September 2017

High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

1 reference

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30 September 2017

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Metabolic effects of fructose and the worldwide increase in obesity.

1 reference

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30 September 2017

Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study

1 reference

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30 September 2017

Subcellular localization of Nox4 and regulation in diabetes

1 reference

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30 September 2017

Association between serum uric acid and development of type 2 diabetes.

1 reference

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30 September 2017

Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

1 reference

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30 September 2017

Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?

1 reference

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30 September 2017

Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey

1 reference

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30 September 2017

High serum uric acid as a novel risk factor for type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

A causal role for uric acid in fructose-induced metabolic syndrome

1 reference

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30 September 2017

The natural history of nonalcoholic fatty liver disease: a population-based cohort study

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30 September 2017

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Control of Plasma and Liver Triglyceride Kinetics by Carbohydrate Metabolism and Insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Fructose: metabolism and short-term effects on carbohydrate and purine metabolic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

30 September 2017

Blood lipids, lipoproteins, apoproteins, and uric acid in men fed diets containing fructose or high-amylose cornstarch

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30 September 2017

Hereditary fructose intolerance in childhood. Diagnosis, management, and course in 55 patients

1 reference

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30 September 2017

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress

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28 June 2018

The mechanism of adenosine triphosphate depletion in the liver after a load of fructose. A kinetic study of liver adenylate deaminase

1 reference

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28 June 2018

Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men.

1 reference

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21 September 2018

Gout and risk of non-alcoholic fatty liver disease.

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21 September 2018

Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction

1 reference

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21 September 2018

Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

21 September 2018

Relationship between uric acid and hepatic steatosis among Koreans

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21 September 2018

Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

21 September 2018

Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells.

1 reference

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21 September 2018

Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction

1 reference

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21 September 2018

Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase

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21 September 2018

Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation

1 reference

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21 September 2018

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2.

1 reference

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21 September 2018

Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study

1 reference

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21 September 2018

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3504786

21 September 2018

Modified reagents for determination of urea and ammonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypouricemic therapy: a novel potential therapeutic option for nonalcoholic fatty liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

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Association between preoperative statin therapy and postoperative change in glomerular filtration rate in endovascular aortic surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uric acid and cardiovascular risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of dietary fructose and sucrose on plasma triglyceride metabolism in patients with endogenous hypertriglyceridemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repressed expression of the human xanthine oxidoreductase gene. E-box and TATA-like elements restrict ground state transcriptional activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fructose-induced hyperuricaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23035112

12 December 2020

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Identifiers

10.1074/JBC.M112.399899

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9 March 2020

1 reference

Europe PubMed Central

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9 March 2020

1 reference

Europe PubMed Central

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9 March 2020

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