Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies (Q36419592)

14 August 2017

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title

Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies (English)

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amyotrophic lateral sclerosis

14 August 2017

main subject

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2

Merit Cudkowicz

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14 August 2017

Lucie I Bruijn

1

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14 August 2017

publication date

1 March 2006

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

14 August 2017

published in

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14 August 2017

volume

6

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14 August 2017

issue

3

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14 August 2017

page(s)

417-428

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Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis

14 August 2017

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Multidisciplinary ALS care improves quality of life in patients with ALS.

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Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996-2000.

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Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis

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Unraveling the mechanisms involved in motor neuron degeneration in ALS

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

21 January 2018

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A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2.

21 January 2018

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Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis

21 January 2018

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Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q.

21 January 2018

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A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

21 January 2018

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DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4)

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Mutant dynactin in motor neuron disease.

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Genetic factors in the early diagnosis of ALS.

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

21 January 2018

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Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease

21 January 2018

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Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

21 January 2018

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

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An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

21 January 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

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Excitotoxicity hypothesis

21 January 2018

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Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

21 January 2018

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Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Excitotoxicity and ALS: what is unique about the AMPA receptors expressed on spinal motor neurons?

21 January 2018

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Glutamate receptors: RNA editing and death of motor neurons

21 January 2018

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Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 January 2018

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes.

21 January 2018

1 reference

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Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution, and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

A possible therapeutic target for Lou Gehrig's disease

21 January 2018

1 reference

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A novel action of histone deacetylase inhibitors in a protein aggresome disease model

21 January 2018

1 reference

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Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

21 January 2018

1 reference

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.

21 January 2018

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Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria

21 January 2018

1 reference

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Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

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Minocycline delays disease onset and mortality in a transgenic model of ALS.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

A randomized sequential trial of creatine in amyotrophic lateral sclerosis

21 January 2018

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A clinical trial of creatine in ALS.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Neuronal intermediate filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Manganese porphyrin given at symptom onset markedly extends survival of ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Can stem cells cross lineage boundaries?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Directed differentiation of embryonic stem cells into motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Specification of motoneurons from human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

GDNF delivery using human neural progenitor cells in a rat model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Neurogenesis and plasticity in the CNS of adult birds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Manipulation of neural precursors in situ: induction of neurogenesis in the neocortex of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Fezl is required for the birth and specification of corticospinal motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Mutations in dynein link motor neuron degeneration to defects in retrograde transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737175.6.3.417

21 January 2018

Identifiers

DOI

10.1586/14737175.6.3.417

1 reference

14 August 2017

1 reference