LRP5/6 in Wnt signaling and tumorigenesis (Q36429587)

14 August 2017

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title

LRP5/6 in Wnt signaling and tumorigenesis (English)

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14 August 2017

Yonghe Li

1

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PubMed ID

16556044

14 August 2017

Guojun Bu

series ordinal

2

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PubMed ID

16556044

14 August 2017

language of work or name

English

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publication date

1 October 2005

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14 August 2017

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14 August 2017

1

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14 August 2017

5

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14 August 2017

673-681

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WNT and beta-catenin signalling: diseases and therapies

14 August 2017

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

LDL receptor relatives at the crossroad of endocytosis and signaling.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Wise, a context-dependent activator and inhibitor of Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

An LDL-receptor-related protein mediates Wnt signalling in mice

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

A mechanism for Wnt coreceptor activation

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Wnt proteins in mammary development and cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Wnt signaling in lung cancer

21 January 2018

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https://api.crossref.org/works/10.2217%2F14796694.1.5.673

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

Expression profile of genes from 12p in testicular germ cell tumors of adolescents and adults associated with i(12p) and amplification at 12p11.2-p12.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14796694.1.5.673

21 January 2018

Identifiers

DOI

10.2217/14796694.1.5.673

1 reference

14 August 2017

1 reference

PubMed ID

16556044