CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. (Q36448119)

14 August 2017

CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. (English)

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14 August 2017

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11

Fatah Kashanchi

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14 August 2017

Denitra Breuer

1

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14 August 2017

Alexander Kotelkin

2

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14 August 2017

Tatiana Ammosova

3

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14 August 2017

Namita Kumari

4

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14 August 2017

Andrey Ivanov

5

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14 August 2017

Andrey V Ilatovskiy

6

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14 August 2017

Monique Beullens

7

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14 August 2017

Philip R Roane

8

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14 August 2017

Mathieu Bollen

9

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14 August 2017

Michael G Petukhov

10

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14 August 2017

Sergei Nekhai

12

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14 August 2017

9 November 2012

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9

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14 August 2017

94

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https://scigraph.springernature.com/pub.10.1186/1742-4690-9-94

14 August 2017

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cites work

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Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation

30 September 2017

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30 September 2017

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Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.

30 September 2017

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Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription

30 September 2017

1 reference

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Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9

30 September 2017

1 reference

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Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

30 September 2017

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microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection

30 September 2017

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Crystal structure of HIV-1 Tat complexed with human P-TEFb

30 September 2017

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HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP

30 September 2017

1 reference

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HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription

30 September 2017

1 reference

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Cyclin-dependent kinase inhibitors: a survey of recent patent literature

30 September 2017

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7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop

30 September 2017

1 reference

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30 September 2017

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PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

30 September 2017

1 reference

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LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

30 September 2017

1 reference

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Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

30 September 2017

1 reference

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Iron chelators ICL670 and 311 inhibit HIV-1 transcription

30 September 2017

1 reference

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Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

30 September 2017

1 reference

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Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Controlling the elongation phase of transcription with P-TEFb

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Tax interacts with P-TEFb in a novel manner to stimulate human T-lymphotropic virus type 1 transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Antiviral activity of CYC202 in HIV-1-infected cells

30 September 2017

1 reference

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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cdk2 knockout mice are viable

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Nuclear protein phosphatase-1 regulates HIV-1 transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cell cycle-regulated transcription by the human immunodeficiency virus type 1 Tat transactivator

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Distinct roles for cyclin-dependent kinases in cell cycle control

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cdk1 is sufficient to drive the mammalian cell cycle

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

RNA interference directed to CDK2 inhibits HIV-1 transcription

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cdc2-cyclin E complexes regulate the G1/S phase transition

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3515335

A bipartite substrate recognition motif for cyclin-dependent kinases

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23140174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

In vivo footprinting studies suggest a role for chromatin in transcription of the human 7SK gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23140174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1742-4690-9-94

1 reference

Dimensions Publication ID

14 August 2017

0 references

1 reference

14 August 2017

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