MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes (Q34394298)

1 August 2017

title

MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes (English)

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1 August 2017

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2

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1 August 2017

Teresa M Wilson

1

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1 August 2017

Stella A Martomo

3

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1 August 2017

Patsa Sullivan

4

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1 August 2017

Li Lan

5

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1 August 2017

Fumio Hanaoka

6

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1 August 2017

Akira Yasui

7

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1 August 2017

Roger Woodgate

8

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1 August 2017

Patricia J Gearhart

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1 August 2017

language of work or name

English

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publication date

14 February 2005

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Journal of Experimental Medicine

1 August 2017

published in

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1 August 2017

volume

201

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1 August 2017

issue

4

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1 August 2017

page(s)

637-645

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describes a project that uses

1 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2213055/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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1 reference

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Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions

6 July 2018

1 reference

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

6 July 2018

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A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

6 July 2018

1 reference

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Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Recombinogenic phenotype of human activation-induced cytosine deaminase.

6 July 2018

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DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

6 July 2018

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YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins

6 July 2018

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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice

6 July 2018

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Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells

6 July 2018

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Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

6 July 2018

1 reference

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Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

6 July 2018

1 reference

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129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

6 July 2018

1 reference

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Replication of damaged DNA.

6 July 2018

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Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

6 July 2018

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AID mediates hypermutation by deaminating single stranded DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

6 July 2018

1 reference

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DNA polymerase kappa deficiency does not affect somatic hypermutation in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

poliota, a remarkably error-prone human DNA polymerase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Mechanisms of accurate translesion synthesis by human DNA polymerase eta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Human exonuclease I interacts with the mismatch repair protein hMSH2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

DNA precursor pools and ribonucleotide reductase activity: distribution between the nucleus and cytoplasm of mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Efficient selection for high-expression transfectants with a novel eukaryotic vector

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Constitutive expression of AID leads to tumorigenesis

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Immunology: the roots of antibody diversity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2213055

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

27 October 2018

1 reference

12 December 2020

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation

1 reference

12 December 2020

Involvement of DNA mismatch repair in folate deficiency-induced apoptosis☆

1 reference

12 December 2020

Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20042066

1 reference

1 August 2017

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1 August 2017

1 reference