Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract (Q36477887)

14 August 2017

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title

Proposed mode of action for in utero effects of some phthalate esters on the developing male reproductive tract (English)

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14 August 2017

Raymond M David

1

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PubMed ID

16698716

14 August 2017

language of work or name

English

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publication date

1 January 2006

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14 August 2017

Toxicologic Pathology

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14 August 2017

34

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14 August 2017

3

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14 August 2017

209-219

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Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Male reproductive tract lesions at 6, 12, and 18 months of age following in utero exposure to di(n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Quantitative Changes in Gene Expression in Fetal Rat Testes following Exposure to Di(n-butyl) Phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Evaluation of reproductive development following intravenous and oral exposure to DEHP in male neonatal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Developmental effects of endocrine-disrupting chemicals in wildlife and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Evaluation of a recombinant yeast cell estrogen screening assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Testicular toxicity and reduced sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Study of 202 Natural, Synthetic, and Environmental Chemicals for Binding to the Androgen Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Pharmacokinetics of dibutylphthalate in pregnant rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Studies on the testicular effects and zinc excretion produced by various isomers of monobutyl-o-phthalate in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effect of DI-n-pentyl phthalate treatment on testicular steroidogenic enzymes and cytochrome P-450 in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effects of phthalate esters on the developing reproductive tract of male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Testicular effects of phthalate esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

The estrogenic activity of phthalate esters in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Long-term effects of intrauterine exposure to mono-n-butyl phthalate on the reproductive function of postnatal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

DI-(2-ethylhexyl) phthalate-induced cell proliferation is involved in the inhibition of gap junctional intercellular communication and blockage of apoptosis in mouse Sertoli cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Exposure in utero to di(n-butyl) phthalate alters the vimentin cytoskeleton of fetal rat Sertoli cells and disrupts Sertoli cell-gonocyte contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effects of mono-(2-ethylhexyl) phthalate on fetal and neonatal rat testis organ cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effect of mono-(2-ethylhexyl)phthalate on follicle-stimulating hormone responsiveness of cultured rat Sertoli cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Abnormal Leydig Cell aggregation in the fetal testis of rats exposed to di (n-butyl) phthalate and its possible role in testicular dysgenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Spermatogonia: stem cells with a great perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Cryptorchidism in mice mutant for Insl3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Proliferation and differentiation of spermatogonial stem cells in the w/wv mutant mouse testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Reversibility of testicular atrophy induced by Di(2-ethylhexyl) phthalate in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effect of phthalic acid esters on gonadal function in male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Minireview: transcriptional regulation of gonadal development and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effect of di(2-ethylhexyl)phthalate (DEHP) on hepatic mixed function oxidases in different animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Effect of phthalate esters on reproduction in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Defining the cellular and molecular mechanisms of toxicant action in the testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Hormones and testis development and the possible adverse effects of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Dose-dependent effect of phthalate ester on testicular descent in pre-and post natal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Profiling gene expression during the differentiation and development of the murine embryonic gonad

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Several environmental oestrogens are also anti-androgens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Differential effects of phthalate esters on transcriptional activities via human estrogen receptors alpha and beta, and androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Inhibition of FSH-stimulated cAMP accumulation and progesterone production by mono(2-ethylhexyl) phthalate in rat granulosa cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

Essential Role of Extracellular Matrix (ECM) Overlay in Establishing the Functional Integrity of Primary Neonatal Rat Sertoli Cell/Gonocyte Co-cultures: An Improved In Vitro Model for Assessment of Male Reproductive Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01926230600642625

10.1080/01926230600642625

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16698716