SREBPs suppress IRS-2-mediated insulin signalling in the liver. (Q47868873)

6 February 2018

title

SREBPs suppress IRS-2-mediated insulin signalling in the liver. (English)

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6 February 2018

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3

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Hirohito Sone

10

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Hitoshi Shimano

2

Hitoshi Shimano

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6 February 2018

Takashi Matsuzaka

4

Takashi Matsuzaka

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6 February 2018

Yoshimi Nakagawa

7

Yoshimi Nakagawa

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6 February 2018

Akimitsu Takahashi

8

Akimitsu Takahashi

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6 February 2018

Hideo Toyoshima

11

Hideo Toyoshima

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6 February 2018

Tomohiro Ide

1

Tomohiro Ide

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6 February 2018

Masanori Nakakuki

5

Masanori Nakakuki

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6 February 2018

author name string

Takashi Yamamoto

6

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6 February 2018

Hiroaki Suzuki

9

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Akiyoshi Fukamizu

12

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6 February 2018

Nobuhiro Yamada

13

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6 February 2018

publication date

14 March 2004

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6 February 2018

published in

Nature Cell Biology

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6 February 2018

volume

6

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6 February 2018

page(s)

351-357

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6 February 2018

issue

4

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6 February 2018

https://scigraph.springernature.com/pub.10.1038/ncb1111

exact match

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cites work

The IRS-signalling system: a network of docking proteins that mediate insulin action

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Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

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7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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7 January 2021

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

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7 January 2021

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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7 January 2021

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse

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7 January 2021

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

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7 January 2021

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

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7 January 2021

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

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7 January 2021

Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes

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7 January 2021

Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.

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7 January 2021

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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7 January 2021

Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

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7 January 2021

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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7 January 2021

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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7 January 2021

Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor

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7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

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7 January 2021

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

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7 January 2021

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

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7 January 2021

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

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7 January 2021

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

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7 January 2021

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

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7 January 2021

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

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7 January 2021

A simplified system for generating recombinant adenoviruses

1 reference

7 January 2021

A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats

1 reference

7 January 2021

Human insulin receptor substrate-2: gene organization and promoter characterization

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7 January 2021

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

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7 January 2021

Identifiers

DOI

10.1038/NCB1111

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6 February 2018

PubMed ID

15048126

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6 February 2018