PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival (Q36490557)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18668521%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival (English)

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11 January 2020

1

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11 January 2020

author name string

Ming M Ruan

series ordinal

2

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11 January 2020

Merry J Oursler

series ordinal

3

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11 January 2020

publication date

1 December 2008

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Journal of Cellular Physiology

11 January 2020

published in

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11 January 2020

volume

217

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11 January 2020

issue

3

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11 January 2020

page(s)

752-758

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Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

11 January 2020

cites work

1 reference

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Oncogenic c-H-ras deregulates survivin expression: an improvement for survival

30 September 2017

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30 September 2017

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MEK1 activation by PAK: a novel mechanism

30 September 2017

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IAP survivin regulates atherosclerotic macrophage survival

30 September 2017

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Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

30 September 2017

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Regulation of Raf-1 by direct feedback phosphorylation.

30 September 2017

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30 September 2017

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Activated H-Ras regulates hematopoietic cell survival by modulating Survivin

30 September 2017

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An IAP-IAP complex inhibits apoptosis

30 September 2017

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Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation

30 September 2017

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Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras

30 September 2017

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Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway

30 September 2017

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Validating survivin as a cancer therapeutic target

30 September 2017

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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes

30 September 2017

1 reference

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PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway.

30 September 2017

1 reference

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Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1

30 September 2017

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Positive and negative regulation of Raf kinase activity and function by phosphorylation

30 September 2017

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Structural basis for the inhibition of caspase-3 by XIAP

30 September 2017

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

30 September 2017

1 reference

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

30 September 2017

1 reference

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

30 September 2017

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TGF-beta enhances osteoclast differentiation in hematopoietic cell cultures stimulated with RANKL and M-CSF.

30 September 2017

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Mitogen-activated protein kinases: specific messages from ubiquitous messengers

30 September 2017

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Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

30 September 2017

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The complexity of Raf-1 regulation

30 September 2017

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

30 September 2017

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

30 September 2017

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Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway.

30 September 2017

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p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

28 June 2018

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Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis.

28 June 2018

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M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

21 September 2018

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Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival.

21 September 2018

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Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.

21 September 2018

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Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation

21 September 2018

1 reference

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21 September 2018

Identifiers

DOI

10.1002/JCP.21550

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11 January 2020

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11 January 2020

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