Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway. (Q42523643)

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English	Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway.	scientific article

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1 January 2020

Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway (English)

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Europe PubMed Central

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1 January 2020

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Elizabeth W Bradley

1

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Ming M Ruan

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Merry J Oursler

3

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15 January 2008

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1 January 2020

Journal of Biological Chemistry

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283

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8055-8064

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1 January 2020

Therapeutic approaches to bone diseases

1 reference

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21 January 2018

Differences in the kinetics of activation of protein kinases and extracellular signal-related protein kinase 1 in colony-stimulating factor 1-stimulated and lipopolysaccharide-stimulated macrophages

1 reference

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21 January 2018

Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival.

1 reference

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21 January 2018

p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function

1 reference

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21 January 2018

Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts

1 reference

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21 January 2018

Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway

1 reference

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21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

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21 January 2018

Early growth response transcriptional regulators are dispensable for macrophage differentiation.

1 reference

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21 January 2018

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription

1 reference

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21 January 2018

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

1 reference

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21 January 2018

The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience.

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21 January 2018

Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells

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21 January 2018

Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo

1 reference

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21 January 2018

The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells

1 reference

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21 January 2018

NAG-1 up-regulation mediated by EGR-1 and p53 is critical for quercetin-induced apoptosis in HCT116 colon carcinoma cells.

1 reference

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21 January 2018

Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth

1 reference

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21 January 2018

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses

1 reference

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21 January 2018

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

1 reference

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21 January 2018

EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

1 reference

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21 January 2018

Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist

1 reference

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21 January 2018

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

1 reference

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21 January 2018

Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL

1 reference

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21 January 2018

Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

BID: a novel BH3 domain-only death agonist

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

The Cbl family proteins: ring leaders in regulation of cell signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation

1 reference

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21 January 2018

Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens

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21 January 2018

M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

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21 January 2018

Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.

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21 January 2018

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

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21 January 2018

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

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21 January 2018

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

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21 January 2018

Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway.

1 reference

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21 January 2018

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

1 reference

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21 January 2018

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

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21 January 2018

Induction of BCL2 family member MCL1 as an early response to DNA damage.

1 reference

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21 January 2018

Rapid turnover of mcl-1 couples translation to cell survival and apoptosis

1 reference

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21 January 2018

In vitro and in vivo assays for osteoclast apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709500200

21 January 2018

Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M709500200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18198176%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18198176%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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