Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. (Q36492499)

14 August 2017

Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. (English)

1 reference

14 August 2017

Troy C Krzysiak

1

1 reference

14 August 2017

Michael Grabe

series ordinal

2

1 reference

14 August 2017

Susan P Gilbert

series ordinal

3

1 reference

14 August 2017

language of work or name

English

0 references

publication date

25 November 2007

1 reference

Journal of Biological Chemistry

14 August 2017

1 reference

14 August 2017

283

1 reference

14 August 2017

4

1 reference

14 August 2017

2078-2087

1 reference

Genes required for mitotic spindle assembly in Drosophila S2 cells

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A structural model for monastrol inhibition of dimeric kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Inhibitors of kinesin motor proteins--research and clinical progress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Cell cycle-dependent dynamics and regulation of mitotic kinesins in Drosophila S2 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Mechanistic analysis of the mitotic kinesin Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Antitumor activity of a kinesin inhibitor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Spindle mechanics and dynamics during mitosis in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

Kinesin's second step

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Inhibition of a mitotic motor protein: where, how, and conformational consequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A force balance model of early spindle pole separation in Drosophila embryos.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A structural change in the kinesin motor protein that drives motility

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Antagonistic microtubule-sliding motors position mitotic centrosomes in Drosophila early embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

The kinesin-like protein KLP61F is essential for mitosis in Drosophila

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Pathway of processive ATP hydrolysis by kinesin.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Kinesin ATPase: rate-limiting ADP release

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Bead movement by single kinesin molecules studied with optical tweezers

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Mitotic spindle organization by a plus-end-directed microtubule motor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

Stepping and stretching. How kinesin uses internal strain to walk processively

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265775

28 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Alternating site mechanism of the kinesin ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Movement of microtubules by single kinesin molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Docking and rolling, a model of how the mitotic motor Eg5 works

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

A mechanistic model for Ncd directionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Fluorescence methods for studying the kinetics and thermodynamics of transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Modulation of Kinesin Half-Site ADP Release and Kinetic Processivity by a Spacer between the Head Groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708354200

Kinetic studies of dimeric Ncd: evidence that Ncd is not processive

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interacting head mechanism of microtubule-kinesin ATPase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18037705

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M708354200

1 reference

14 August 2017

1 reference

14 August 2017

1 reference