Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis (Q36495172)

14 August 2017

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title

Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis (English)

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14 August 2017

Ulrich Beuers

1

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PubMed ID

16741551

14 August 2017

language of work or name

English

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publication date

1 June 2006

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Nature Reviews Gastroenterology & Hepatology

14 August 2017

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14 August 2017

3

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14 August 2017

6

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14 August 2017

318-328

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https://scigraph.springernature.com/pub.10.1038/ncpgasthep0521

14 August 2017

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Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver

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Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase

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21 January 2018

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Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis

21 January 2018

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Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes

21 January 2018

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Characterization of the mouse bile salt export pump overexpressed in the baculovirus system

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Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas.

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Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation

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Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes

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Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner

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No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis

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21 January 2018

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Effect of high-dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing cholangitis

21 January 2018

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Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles

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21 January 2018

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Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration

21 January 2018

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Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease

21 January 2018

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The effect of ursodeoxycholic acid therapy on liver fibrosis progression in primary biliary cirrhosis

21 January 2018

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Formation of iso-ursodeoxycholic acid during administration of ursodeoxycholic acid in man.

21 January 2018

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21 January 2018

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21 January 2018

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Pharmacology of ursodeoxycholic acid, an enterohepatic drug.

21 January 2018

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7 January 2021

Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Treatment of primary biliary cirrhosis

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https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Influence of cholestasis on absorption of ursodeoxycholic acid

1 reference

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7 January 2021

Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Biliary transport systems: short-term regulation

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of tauroursodeoxycholic acid on bile-acid-induced apoptosis and cytolysis in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Assessment of biliary bicarbonate secretion in humans by positron emission tomography

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Effect of ursodeoxycholic acid on the kinetics of cholic acid and chenodeoxycholic acid in patients with primary sclerosing cholangitis

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Immunomodulatory effects of ursodeoxycholic acid on immune responses

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat

1 reference

https://api.crossref.org/works/10.1038%2FNCPGASTHEP0521

7 January 2021

Identifiers

DOI

10.1038/NCPGASTHEP0521

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14 August 2017

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PubMed ID

16741551