TGF-β upregulates miR-181a expression to promote breast cancer metastasis (Q36497263)

14 August 2017

TGF-β upregulates miR-181a expression to promote breast cancer metastasis. (English)

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14 August 2017

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Molly A Taylor

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14 August 2017

Khalid Sossey-Alaoui

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14 August 2017

Cheryl L Thompson

3

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14 August 2017

David Danielpour

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14 August 2017

William P Schiemann

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14 August 2017

language of work or name

English

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publication date

17 December 2012

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Journal of Clinical Investigation

14 August 2017

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14 August 2017

123

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1

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14 August 2017

150-163

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3533297/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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miR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients

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MicroRNA-181a - a tale of discrepancies

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miR-181a sensitizes a multidrug-resistant leukemia cell line K562/A02 to daunorubicin by targeting BCL-2.

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Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition

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Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer.

30 September 2017

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Lysyl oxidase contributes to mechanotransduction-mediated regulation of transforming growth factor-β signaling in breast cancer cells

30 September 2017

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Noncanonical TGF-β signaling during mammary tumorigenesis

30 September 2017

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miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors

30 September 2017

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miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras

30 September 2017

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WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade

30 September 2017

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Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM.

30 September 2017

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The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors

30 September 2017

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MicroRNAs and metastasis: little RNAs go a long way

30 September 2017

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Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment

30 September 2017

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The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells

30 September 2017

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MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2.

30 September 2017

1 reference

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miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines

30 September 2017

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TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.

30 September 2017

1 reference

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

30 September 2017

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p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity.

30 September 2017

1 reference

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Metastamir: the field of metastasis-regulatory microRNA is spreading

30 September 2017

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The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling

30 September 2017

1 reference

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Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors

30 September 2017

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X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression

30 September 2017

1 reference

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Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

30 September 2017

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Many roads to maturity: microRNA biogenesis pathways and their regulation

30 September 2017

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A tense situation: forcing tumour progression

30 September 2017

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Non-Smad pathways in TGF-beta signaling

30 September 2017

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Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

30 September 2017

1 reference

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Three-dimensional context regulation of metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

SMAD proteins control DROSHA-mediated microRNA maturation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

miRiad roles for the miR-17-92 cluster in development and disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533297

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

30 September 2017

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Three-dimensional culture models of normal and malignant breast epithelial cells

30 September 2017

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A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes

30 September 2017

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Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells

30 September 2017

1 reference

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RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

30 September 2017

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

30 September 2017

1 reference

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The use of cystatin C to inhibit epithelial-mesenchymal transition and morphological transformation stimulated by transforming growth factor-beta

30 September 2017

1 reference

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The tension mounts: mechanics meets morphogenesis and malignancy

30 September 2017

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30 September 2017

Human MicroRNA targets

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

30 September 2017

1 reference

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FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

30 September 2017

1 reference

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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades

30 September 2017

1 reference

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Gene expression profiling predicts clinical outcome of breast cancer

30 September 2017

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Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

30 September 2017

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30 September 2017

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TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

30 September 2017

1 reference

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Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor

30 September 2017

1 reference

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miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.

30 September 2017

1 reference

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Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim.

21 September 2018

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Hematopoiesis-related microRNA expression in myelodysplastic syndromes.

21 September 2018

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Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth

21 September 2018

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Epigenetic down-regulation of BIM expression is associated with reduced optimal responses to imatinib treatment in chronic myeloid leukaemia.

21 September 2018

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21 September 2018

Identifiers

DOI

10.1172/JCI64946

1 reference

14 August 2017

1 reference

14 August 2017

1 reference