One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. (Q36498762)

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English	One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.	scientific article

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8 January 2020

One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications (English)

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8 January 2020

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8 January 2020

Maximiliano J Jiménez-Dalmaroni

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8 January 2020

Maria G. Castro

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8 January 2020

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Kurt M Kroeger

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8 January 2020

Mariana Puntel

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8 January 2020

Alison J Rapaport

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8 January 2020

Daniel Larocque

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8 January 2020

Gwendalyn D King

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8 January 2020

Stephen A Johnson

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8 January 2020

Chunyan Liu

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8 January 2020

Weidong Xiong

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8 January 2020

Marianela Candolfi

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8 January 2020

Sonali Mondkar

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8 January 2020

Philip Ng

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8 January 2020

Donna Palmer

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8 January 2020

Pedro R Lowenstein

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25 September 2007

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8 January 2020

Molecular Therapy

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8 January 2020

15

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8 January 2020

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8 January 2020

2154-2163

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8 January 2020

Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.

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30 September 2017

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

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30 September 2017

Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses.

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30 September 2017

The innate immune response to adenovirus vectors

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30 September 2017

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Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

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Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination

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30 September 2017

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

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Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.

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30 September 2017

Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors

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Adenovirus vector-infected cells can escape adenovirus antigen-specific cytotoxic T-lymphocyte killing in vivo

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A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

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Role of T cells in inflammation caused by adenovirus vectors in the brain.

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Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors

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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

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28 June 2018

Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain

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28 June 2018

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

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28 June 2018

Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.

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28 June 2018

Immune responses to adenoviral vectors during gene transfer in the brain

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28 June 2018

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28 June 2018

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

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21 September 2018

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21 September 2018

Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS.

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21 September 2018

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

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21 September 2018

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21 September 2018

Un pour tous, tous pour un.

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21 September 2018

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

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10.1038/SJ.MT.6300305

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8 January 2020

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