Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro (Q36509143)

14 August 2017

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro (English)

1 reference

14 August 2017

Yaïr Botbol

1

1 reference

14 August 2017

Nidhanapati K Raghavendra

2

1 reference

14 August 2017

Shaila Rahman

3

1 reference

14 August 2017

Alan Engelman

4

1 reference

14 August 2017

Marc Lavigne

5

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14 August 2017

language of work or name

English

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publication date

3 January 2008

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14 August 2017

Nucleic Acids Research

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14 August 2017

36

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14 August 2017

4

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14 August 2017

1237-1246

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describes a project that uses

14 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2275106/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

1 reference

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HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications

30 September 2017

1 reference

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Molecular mechanisms of HIV integration and therapeutic intervention

30 September 2017

1 reference

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Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration

30 September 2017

1 reference

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An essential role for LEDGF/p75 in HIV integration

30 September 2017

1 reference

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Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness

30 September 2017

1 reference

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Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

30 September 2017

1 reference

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Retroviral DNA integration: viral and cellular determinants of target-site selection

30 September 2017

1 reference

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Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin

30 September 2017

1 reference

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A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

A role for LEDGF/p75 in targeting HIV DNA integration

30 September 2017

1 reference

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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

30 September 2017

1 reference

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

30 September 2017

1 reference

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Construction and analysis of cells lacking the HMGA gene family.

30 September 2017

1 reference

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Transcription start regions in the human genome are favored targets for MLV integration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

HIV-1 integration in the human genome favors active genes and local hotspots

30 September 2017

1 reference

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Generation and interconversion of multiple distinct nucleosomal states as a mechanism for catalyzing chromatin fluidity

30 September 2017

1 reference

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Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Activity of recombinant HIV-1 integrase on mini-HIV DNA.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes

30 September 2017

1 reference

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Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Artificial nucleosome positioning sequences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Retroviral DNA integration directed by HIV integration protein in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Chapter 16 Control of Class II Gene Transcription during in Vitro Nucleosome Assembly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

A nucleoprotein complex mediates the integration of retroviral DNA.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Retroviral integration into minichromosomes in vitro

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Histone acetyltransferase complexes stabilize swi/snf binding to promoter nucleosomes.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2275106

The influence of DNA and nucleosome structure on integration events directed by HIV integrase

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18174227

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18174227

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKM1127

1 reference

14 August 2017

1 reference

14 August 2017

1 reference