Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review]. (Q36511643)

14 August 2017

1 reference

title

Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [review]. (English)

1 reference

14 August 2017

Michele A Zacks

1

1 reference

14 August 2017

Nisha Garg

series ordinal

2

1 reference

14 August 2017

publication date

1 May 2006

1 reference

Molecular Membrane Biology

14 August 2017

published in

1 reference

14 August 2017

volume

23

1 reference

14 August 2017

issue

3

1 reference

14 August 2017

page(s)

209-225

1 reference

14 August 2017

cites work

What can GPI do for you?

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Colworth Medal Lecture. Glycosyl-phosphatidylinositol membrane anchors: the tale of a tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The surface glycoconjugates of trypanosomatid parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Biosynthesis of glycophosphoinositol anchors in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Regulation of host cell function by glycosylphosphatidylinositols of the parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Mammalian GPI proteins: sorting, membrane residence and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The role of phosphoglycans in Leishmania-sand fly interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Glycobiology of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Surface antigens of Toxoplasma gondii: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Secretory pathway of trypanosomatid parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Phosphatidylinositol hydrolysis by Trypanosoma brucei glycosylphosphatidylinositol phospholipase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Phosphoinositides and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Nuclear inositol lipid metabolism: more than just second messenger generation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A ricin agglutinin-resistant clone of Leishmania donovani deficient in lipophosphoglycan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Ricin-resistant mutants of Leishmania major which express modified lipophosphoglycan remain infective for mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Persistence without pathology in phosphoglycan-deficient Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A defect in glycosylphosphatidylinositol (GPI) transamidase activity in mutant K cells is responsible for their inability to display GPI surface proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

No glycolipid anchors are added to Thy-1 glycoprotein in Thy-1-negative mutant thymoma cells of four different complementation classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Molecular genetics of paroxysmal nocturnal hemoglobinuria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Enhanced responses of glycosylphosphatidylinositol anchor-deficient T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

GPI-anchor deficiency in myeloid cells causes impaired FcgammaR effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A new method for predicting signal sequence cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Signal sequences specify the targeting route to the endoplasmic reticulum membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Recognition of the carboxyl-terminal signal for GPI modification requires translocation of its hydrophobic domain across the ER membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

How glycosylphosphatidylinositol-anchored membrane proteins are made

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Selectivity at the cleavage/attachment site of phosphatidylinositol-glycan anchored membrane proteins is enzymatically determined

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Biosynthesis of glycosylphosphatidylinositol (GPI)-anchored membrane proteins in intact cells: specific amino acid requirements adjacent to the site of cleavage and GPI attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Fusion of sequence elements from non-anchored proteins to generate a fully functional signal for glycophosphatidylinositol membrane anchor attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Requirements for glycosylphosphatidylinositol attachment are similar but not identical in mammalian cells and parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Early lipid intermediates in glycosyl-phosphatidylinositol anchor assembly are synthesized in the ER and located in the cytoplasmic leaflet of the ER membrane bilayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The GPI anchor of cell-surface proteins is synthesized on the cytoplasmic face of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

New fluorescent probes reveal that flippase-mediated flip-flop of phosphatidylinositol across the endoplasmic reticulum membrane does not depend on the stereochemistry of the lipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Evidence that the putative COOH-terminal signal transamidase involved in glycosylphosphatidylinositol protein synthesis is present in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Transfer of glycosyl-phosphatidylinositol membrane anchors to polypeptide acceptors in a cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Glycosyl-phosphatidylinositol anchor attachment in a yeast in vitro system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: cleavage of the nascent protein and addition of the PI-G moiety depend on the size of the COOH-terminal signal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of gamma-glutamyl transpeptidase by maleate; identity of a rat kidney maleate-stimulated glutaminase and gamma-glutamyl transpeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Ke 6 gene. Sequence and organization and aberrant regulation in murine polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

COOH-terminal processing of nascent polypeptides by the glycosylphosphatidylinositol transamidase in the presence of hydrazine is governed by the same parameters as glycosylphosphatidylinositol addition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Identification of six complementation classes involved in the biosynthesis of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Identification of SPT14/CWH6 as the yeast homologue of hPIG-A, a gene involved in the biosynthesis of GPI anchors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Processing and trafficking of Leishmania mexicana GP63. Analysis using GP18 mutants deficient in glycosylphosphatidylinositol protein anchoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Families of cysteine peptidases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

MEROPS: the peptidase database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A putative vacuolar processing protease is regulated by ethylene and also during fruit ripening in Citrus fruit

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Vacuolar processing enzymes are essential for proper processing of seed storage proteins in Arabidopsis thaliana

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Isolation and analysis of cDNA encoding a precursor of Canavalia ensiformis asparaginyl endopeptidase (legumain).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol-anchor attachment: photocrosslinking studies in a cell-free system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Early events in glycosylphosphatidylinositol anchor addition. substrate proteins associate with the transamidase subunit gpi8p

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The GPI transamidase complex of Saccharomyces cerevisiae contains Gaa1p, Gpi8p, and Gpi16p

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The Genome of the African Trypanosome Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

The genome of the kinetoplastid parasite, Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F09687860600601494

10.1080/09687860600601494

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference