Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane (Q36557973)

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6 February 2020

title

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane (English)

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6 February 2020

author name string

Patricia A Egner

2

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6 February 2020

Abena S Agyeman

3

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6 February 2020

Kala Visvanathan

4

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6 February 2020

John D Groopman

5

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6 February 2020

Jian-Guo Chen

6

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6 February 2020

Tao-Yang Chen

7

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6 February 2020

Jed W Fahey

8

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6 February 2020

publication date

1 January 2013

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Topics in Current Chemistry

6 February 2020

published in

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6 February 2020

volume

329

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6 February 2020

page(s)

163-177

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Notes from the field: "green" chemoprevention as frugal medicine

6 February 2020

cites work

1 reference

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Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice

30 September 2017

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Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

30 September 2017

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Modification of keap1 cysteine residues by sulforaphane

30 September 2017

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Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

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When NRF2 talks, who's listening?

30 September 2017

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

30 September 2017

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30 September 2017

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

30 September 2017

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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

30 September 2017

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

30 September 2017

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Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

30 September 2017

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

30 September 2017

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Prospective type 1 and type 2 disulfides of Keap1 protein.

30 September 2017

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Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis

30 September 2017

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Discovery and development of sulforaphane as a cancer chemopreventive phytochemical

30 September 2017

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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis

30 September 2017

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Chemoprotection against cancer: an idea whose time has come

30 September 2017

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Molecular basis for chemoprevention by sulforaphane: a comprehensive review.

30 September 2017

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Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis

30 September 2017

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

30 September 2017

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Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

30 September 2017

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Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China

30 September 2017

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Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

30 September 2017

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Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

30 September 2017

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

30 September 2017

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Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk

30 September 2017

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Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

30 September 2017

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Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

30 September 2017

1 reference

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

30 September 2017

1 reference

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Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

30 September 2017

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Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer

30 September 2017

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

30 September 2017

1 reference

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The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

30 September 2017

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Effects of watercress consumption on urinary metabolites of nicotine in smokers

30 September 2017

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Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

30 September 2017

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Chemoprevention by inducers of carcinogen detoxication enzymes

30 September 2017

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30 September 2017

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Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

30 September 2017

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A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

30 September 2017

1 reference

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Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

30 September 2017

1 reference

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Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

28 June 2018

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Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

28 June 2018

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Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 September 2018

1 reference

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Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

21 September 2018

1 reference

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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

21 September 2018

1 reference

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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 September 2018

1 reference

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Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

21 September 2018

1 reference

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Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

21 September 2018

1 reference

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Agents, biomarkers, and cohorts for chemopreventive agent development in prostate cancer

21 September 2018

1 reference

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Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

21 September 2018

1 reference

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Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables

21 September 2018

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12 December 2020

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China

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12 December 2020

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

1 reference

12 December 2020

Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells

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12 December 2020

Identifiers

DOI

10.1007/128_2012_339

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22752583%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22752583%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

22752583

1 reference