Artificial chromosome-based transgenes in the study of genome function (Q36560563)

14 August 2017

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title

Artificial chromosome-based transgenes in the study of genome function (English)

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14 August 2017

Sarah K Bronson

2

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author name string

Jason D Heaney

series ordinal

1

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PubMed ID

16897340

14 August 2017

language of work or name

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4 August 2006

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14 August 2017

17

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inferred from page(s)

published in

Mammalian Genome

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14 August 2017

17

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14 August 2017

8

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14 August 2017

791-807

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https://scigraph.springernature.com/pub.10.1007/s00335-006-0023-9

14 August 2017

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cites work

Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

High-level rearrangement and transcription of yeast artificial chromosome-based mouse Ig kappa transgenes containing distal regions of the contig

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

Fine structure of the human hypoxanthine phosphoribosyltransferase gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

Extrachromosomal and chromosomal gene conversion in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

Homology dependence of targeted recombination at the Chinese hamster APRT locus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00335-006-0023-9

Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells

21 January 2018

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12 December 2020

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.

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12 December 2020

Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis

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12 December 2020

Analysis of the structural integrity of YACs comprising human immunoglobulin genes in yeast and in embryonic stem cells

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12 December 2020

Chromosomal silencing and localization are mediated by different domains of Xist RNA.

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12 December 2020

Heterochromatin effects on the frequency and duration of LCR-mediated gene transcription.

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12 December 2020

A model system to assess the integrity of mammalian YACs during transformation and propagation in yeast

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12 December 2020

Insertional mutation in a transgenic mouse allelic with Purkinje cell degeneration

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12 December 2020

A cre-lox recombination system for the targeted integration of circular yeast artificial chromosomes into embryonic stem cells

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12 December 2020

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

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12 December 2020

Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium

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12 December 2020

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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12 December 2020

A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites.

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci

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12 December 2020

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

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12 December 2020

Foreign DNA integration. Genome-wide perturbations of methylation and transcription in the recipient genomes

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12 December 2020

Position effects are influenced by the orientation of a transgene with respect to flanking chromatin

1 reference

12 December 2020

Production of a model for Lesch-Nyhan syndrome in hypoxanthine phosphoribosyltransferase-deficient mice

1 reference

12 December 2020

Segmental genomic replacement in embryonic stem cells by double lox targeting

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12 December 2020

Transgenic targeting with regulatory elements of the human CD34 gene

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12 December 2020

Isolation of an allele of reeler by insertional mutagenesis

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12 December 2020

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12 December 2020

Testicular degeneration in Bclw-deficient mice

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12 December 2020

Recovery and potential utility of YACs as circular YACs/BACs

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12 December 2020

Structural instability of human tandemly repeated DNA sequences cloned in yeast artificial chromosome vectors

1 reference

12 December 2020

Single-copy transgenic mice with chosen-site integration

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12 December 2020

Specific expression of a foreign β-globin gene in erythroid cells of transgenic mice

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12 December 2020

Construction and characterization of a human bacterial artificial chromosome library

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12 December 2020

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.

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12 December 2020

Gene knock-out technology: a methodological overview for the interested novice

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12 December 2020

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector

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12 December 2020

The "beta-like-globin" gene domain in human erythroid cells

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12 December 2020

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

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12 December 2020

Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication

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12 December 2020

Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy

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12 December 2020

Chromatin insulators and boundaries: effects on transcription and nuclear organization

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12 December 2020

Structure and function of the F plasmid genes essential for partitioning.

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12 December 2020

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

1 reference

12 December 2020

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

1 reference

12 December 2020

Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination

1 reference

12 December 2020

Chromatin modification and epigenetic reprogramming in mammalian development

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12 December 2020

Formation of beta-amyloid protein deposits in brains of transgenic mice

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12 December 2020

Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice

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12 December 2020

Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

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12 December 2020

Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation

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12 December 2020

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

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12 December 2020

A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice

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12 December 2020

Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells.

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12 December 2020

A nuclear DNA attachment element mediates elevated and position-independent gene activity

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12 December 2020

Transgenic mice generated by pronuclear injection of a yeast artificial chromosome.

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12 December 2020

Modification and manipulation of mammalian DNA cloned as YACs

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12 December 2020

A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment

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12 December 2020

Position effects in mice carrying a lacZ transgene in cis with the beta-globin LCR can be explained by a graded model

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12 December 2020

Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells

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12 December 2020

Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors

1 reference

12 December 2020

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

1 reference

12 December 2020

Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome.

1 reference

12 December 2020

Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells

1 reference

12 December 2020

The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene

1 reference

12 December 2020

Modular bacterial artificial chromosome vectors for transfer of large inserts into mammalian cells

1 reference

12 December 2020

LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs.

1 reference

12 December 2020

A new bacteriophage P1-derived vector for the propagation of large human DNA fragments

1 reference

12 December 2020

Cardiac expression of Gal4 causes cardiomyopathy in a dose-dependent manner.

1 reference

12 December 2020

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

1 reference

12 December 2020

Locus control region function and heterochromatin-induced position effect variegation

1 reference

12 December 2020

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1 reference

12 December 2020

A genetically clamped renin transgene for the induction of hypertension

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12 December 2020

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

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12 December 2020

Recombination during transformation as a source of chimeric mammalian artificial chromosomes in yeast (YACs)

1 reference

12 December 2020

Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene

1 reference

12 December 2020

Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies

1 reference

12 December 2020

Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange

1 reference

12 December 2020

Germ line transmission of a yeast artificial chromosome spanning the murine alpha 1(I) collagen locus

1 reference

12 December 2020

Stable propagation of cosmid sized human DNA inserts in an F factor based vector

1 reference

12 December 2020

Size matters: use of YACs, BACs and PACs in transgenic animals

1 reference

12 December 2020

Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

1 reference

12 December 2020

Bacteriophage P1 cloning system for the isolation, amplification, and recovery of DNA fragments as large as 100 kilobase pairs

1 reference

12 December 2020

A combinatorial network of evolutionarily conserved myelin basic protein regulatory sequences confers distinct glial-specific phenotypes

1 reference

12 December 2020

Repeat-induced gene silencing in mammals.

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12 December 2020

Transgenic bcl-2 is not sufficient to rescue all hematolymphoid defects in STAT5A/5B-deficient mice

1 reference

12 December 2020

Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice

1 reference

12 December 2020

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue

1 reference

12 December 2020

Introduction of a rabbit beta-globin gene into the mouse germ line

1 reference

12 December 2020

Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice

1 reference

12 December 2020

Position-effect variegation and the new biology of heterochromatin

1 reference

12 December 2020

P1 site-specific recombination: nucleotide sequence of the recombining sites

1 reference

12 December 2020

A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice

1 reference

12 December 2020

Second-generation approach to the construction of yeast artificial-chromosome libraries

1 reference

12 December 2020

A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA

1 reference

12 December 2020

The structure of the human CD2 gene and its expression in transgenic mice

1 reference

12 December 2020

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

1 reference

12 December 2020

Rapid modification of bacterial artificial chromosomes by ET-recombination.

1 reference

12 December 2020

A method for the generation of YAC transgenic mice by pronuclear microinjection

1 reference

12 December 2020

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

12 December 2020

The influence of chromosomal location on the expression of two transgenes in mice

1 reference

12 December 2020

Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.

1 reference

12 December 2020

Human gamma- to beta-globin gene switching in transgenic mice.

1 reference

12 December 2020

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

1 reference

12 December 2020

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

1 reference

12 December 2020

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1 reference

12 December 2020

Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome

1 reference

12 December 2020

High frequency targeting of genes to specific sites in the mammalian genome

1 reference

12 December 2020

Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: establishment of new HPRT-deficient mouse embryonic stem cell lines

1 reference

12 December 2020

Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.

1 reference

12 December 2020

Generation of a nested series of interstitial deletions in yeast artificial chromosomes carrying human DNA.

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12 December 2020

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA

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12 December 2020

RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein

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12 December 2020

The organization of the human HPRT gene

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12 December 2020

A BAC transgenic analysis of the Mrf4/Myf5 locus reveals interdigitated elements that control activation and maintenance of gene expression during muscle development

1 reference

12 December 2020

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

1 reference

12 December 2020

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

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12 December 2020

Germ-line transmission and expression of a human-derived yeast artificial chromosome

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12 December 2020

Conspiracy of silence among repeated transgenes.

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12 December 2020

Accurate modification of a chromosomal plasmid by homologous recombination in human cells

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12 December 2020

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

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12 December 2020

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12 December 2020

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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12 December 2020

Position-dependent variegation of globin transgene expression in mice

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12 December 2020

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.

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12 December 2020

Functional expression and germline transmission of a human chromosome fragment in chimaeric mice

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12 December 2020

Conserved enhancer in the serum response factor promoter controls expression during early coronary vasculogenesis.

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12 December 2020

Effects of altered gene order or orientation of the locus control region on human beta-globin gene expression in mice.

1 reference

12 December 2020

Large-insert BAC/YAC libraries for selective re-isolation of genomic regions by homologous recombination in yeast

1 reference

12 December 2020

Mechanisms involved in targeted gene replacement in mammalian cells

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12 December 2020

Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression

1 reference

12 December 2020

Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences

1 reference

12 December 2020

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

1 reference

12 December 2020

The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice.

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12 December 2020

Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes.

1 reference

12 December 2020

Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice

1 reference

12 December 2020

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

12 December 2020

The beta-globin locus control region enhances transcription of but does not confer position-independent expression onto the lacZ gene in transgenic mice.

1 reference

12 December 2020

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1 reference

12 December 2020

10.1007/S00335-006-0023-9

Identifiers

DOI

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14 August 2017

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PubMed ID

16897340