MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma (Q36580732)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23201752%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma (English)

1 reference

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19 February 2020

0 references

1 reference

angiogenesis inhibitor

1 reference

1 reference

2

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19 February 2020

Clévio Nóbrega

3

1 reference

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19 February 2020

Luis Pereira De Almeida

4

1 reference

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19 February 2020

Maria C Pedroso de Lima

7

1 reference

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19 February 2020

author name string

Pedro M Costa

1

1 reference

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19 February 2020

Jeffrey N Bruce

5

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19 February 2020

Peter Canoll

6

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19 February 2020

publication date

30 November 2012

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19 February 2020

published in

Human Molecular Genetics

1 reference

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19 February 2020

volume

22

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19 February 2020

issue

5

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19 February 2020

page(s)

904-918

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Inflammation meets cancer, with NF-κB as the matchmaker

19 February 2020

cites work

1 reference

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Downregulation of Pdcd4 by mir-21 facilitates glioblastoma proliferation in vivo

9 September 2017

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Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype

9 September 2017

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PI3Kinase signaling in glioblastoma

9 September 2017

1 reference

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Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia.

9 September 2017

1 reference

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Phase II study of sunitinib malate in patients with recurrent high-grade glioma.

9 September 2017

1 reference

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Novel targeted agents for platelet-derived growth factor receptor and c-KIT in malignant gliomas

9 September 2017

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Mammalian microRNAs predominantly act to decrease target mRNA levels

9 September 2017

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p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

9 September 2017

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Advances in the treatment of malignant gliomas

9 September 2017

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

9 September 2017

1 reference

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MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

The microRNA network and tumor metastasis

9 September 2017

1 reference

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miR-21 as a key regulator of oncogenic processes

9 September 2017

1 reference

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Emerging functions of microRNAs in glioblastoma

9 September 2017

1 reference

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

9 September 2017

1 reference

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Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells

9 September 2017

1 reference

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miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors

9 September 2017

1 reference

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MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

p53 and NF-kappaB crosstalk: IKKalpha tips the balance

9 September 2017

1 reference

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Genetic pathways to primary and secondary glioblastoma

9 September 2017

1 reference

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MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Oncomirs - microRNAs with a role in cancer

9 September 2017

1 reference

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A microRNA expression signature of human solid tumors defines cancer gene targets

9 September 2017

1 reference

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Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma

9 September 2017

1 reference

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Over-representation of specific regions of chromosome 22 in cells from human glioma correlate with resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea.

9 September 2017

1 reference

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A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

9 September 2017

1 reference

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Extensive modulation of a set of microRNAs in primary glioblastoma

9 September 2017

1 reference

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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNAs: genomics, biogenesis, mechanism, and function

9 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

9 September 2017

https://api.crossref.org/works/10.1093%2FHMG%2FDDS496

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

A new mathematical model for relative quantification in real-time RT-PCR

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

A novel transformation suppressor, Pdcd4, inhibits AP-1 transactivation but not NF-kappaB or ODC transactivation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.

9 September 2017

1 reference

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Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.

30 September 2017

1 reference

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Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

miRNA in situ hybridization in formaldehyde and EDC-fixed tissues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Expression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

The p53 family in differentiation and tumorigenesis.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561912

miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23201752

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDS496

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23201752%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23201752%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

23201752

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23201752%20AND%20SRC:MED&resulttype=core&format=json