The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition (Q36583525)

15 August 2017

1 reference

title

The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition (English)

1 reference

15 August 2017

1

Sylvane Desrivières

0 references

author name string

Christian Kunz

2

1 reference

15 August 2017

Itamar Barash

3

1 reference

15 August 2017

Vida Vafaizadeh

4

1 reference

15 August 2017

Corina Borghouts

5

1 reference

15 August 2017

Bernd Groner

6

1 reference

15 August 2017

1 January 2006

1 reference

Journal of Mammary Gland Biology and Neoplasia

15 August 2017

1 reference

15 August 2017

11

1 reference

15 August 2017

1

1 reference

15 August 2017

75-87

1 reference

https://scigraph.springernature.com/pub.10.1007/s10911-006-9014-4

15 August 2017

0 references

cites work

Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

Roles and regulation of stat family transcription factors in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-006-9014-4

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

1 reference

12 December 2020

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

1 reference

12 December 2020

Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells

1 reference

12 December 2020

The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

1 reference

12 December 2020

Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

1 reference

12 December 2020

Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling

1 reference

12 December 2020

In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.

1 reference

12 December 2020

Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis

1 reference

12 December 2020

The role of signal transducer and activator of transcription factors in leukemogenesis

1 reference

12 December 2020

Turning off signal transducer and activator of transcription (STAT): the negative regulation of STAT signaling

1 reference

12 December 2020

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

1 reference

12 December 2020

JAK/STAT signal transduction: regulators and implication in hematological malignancies

1 reference

12 December 2020

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1 reference

12 December 2020

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast

1 reference

12 December 2020

Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway

1 reference

12 December 2020

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

1 reference

12 December 2020

COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis

1 reference

12 December 2020

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila

1 reference

12 December 2020

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

1 reference

12 December 2020

15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells

1 reference

12 December 2020

Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer

1 reference

12 December 2020

Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function

1 reference

12 December 2020

Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo

1 reference

12 December 2020

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

1 reference

12 December 2020

Targeting the STAT pathway in head and neck cancer: recent advances and future prospects.

1 reference

12 December 2020

Constitutive activation of Stat5b contributes to carcinogenesis in vivo

1 reference

12 December 2020

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

1 reference

12 December 2020

Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck

1 reference

12 December 2020

STAT proteins: From normal control of cellular events to tumorigenesis

1 reference

12 December 2020

JAKs, STATs and Src kinases in hematopoiesis

1 reference

12 December 2020

Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)

1 reference

12 December 2020

STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

1 reference

12 December 2020

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

1 reference

12 December 2020

Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells

1 reference

12 December 2020

Signal transducer and activator of transcription 5 (STAT5), a crucial regulator of immune and cancer cells

1 reference

12 December 2020

DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

1 reference

12 December 2020

Inhibition of transcription factor Stat5 induces cell death of human prostate cancer cells

1 reference

12 December 2020

SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells

1 reference

12 December 2020

Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a

1 reference

12 December 2020

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1 reference

12 December 2020

Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5

1 reference

12 December 2020

Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth

1 reference

12 December 2020

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

1 reference

12 December 2020

GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction

1 reference

12 December 2020

STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression.

1 reference

12 December 2020

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

1 reference

12 December 2020

Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach

1 reference

12 December 2020

Information networks in the mammary gland.

1 reference

12 December 2020

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

1 reference

12 December 2020

Signaling pathways in mammary gland development.

1 reference

12 December 2020

Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice

1 reference

12 December 2020

Autocrine prolactin as a promotor of mammary tumour growth.

1 reference

12 December 2020

Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells

1 reference

12 December 2020

STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalpha.

1 reference

12 December 2020

Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3

1 reference

12 December 2020

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

1 reference

12 December 2020

Coactivators in gene regulation by STAT5.

1 reference

12 December 2020

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

1 reference

12 December 2020

STAT proteins as novel targets for cancer drug discovery

1 reference

12 December 2020

Stat5a/b are essential for normal lymphoid development and differentiation

1 reference

12 December 2020

STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells.

1 reference

12 December 2020

Roles of STAT3 defined by tissue-specific gene targeting

1 reference

12 December 2020

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

1 reference

12 December 2020

Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells.

1 reference

12 December 2020

Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.

1 reference

12 December 2020

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

1 reference

12 December 2020

Targeting transcription factors for cancer therapy

1 reference

12 December 2020

Enforced activation of STAT5A facilitates the generation of embryonic stem-derived hematopoietic stem cells that contribute to hematopoiesis in vivo

1 reference

12 December 2020

Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas

1 reference

12 December 2020

Stat5 tetramer formation is associated with leukemogenesis

1 reference

12 December 2020

Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

1 reference

12 December 2020

SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway

1 reference

12 December 2020

Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.

1 reference

12 December 2020

PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit

1 reference

12 December 2020

A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor

1 reference

12 December 2020

Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.

1 reference

12 December 2020

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

1 reference

12 December 2020

Functional interactions between Stat5 and the glucocorticoid receptor

1 reference

12 December 2020

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

1 reference

12 December 2020

Regulation of gene-activation pathways by PIAS proteins in the immune system

1 reference

12 December 2020

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases

1 reference

12 December 2020

STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta

1 reference

12 December 2020

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

1 reference

12 December 2020

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.

1 reference

12 December 2020

Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter

1 reference

12 December 2020

Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

1 reference

12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

1 reference

12 December 2020

Identification of JAK/STAT signalling components by genome-wide RNA interference.

1 reference

12 December 2020

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma

1 reference

12 December 2020

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence

1 reference

12 December 2020

The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

1 reference

12 December 2020

A new modality for immunosuppression: targeting the JAK/STAT pathway

1 reference

12 December 2020

The role of STATs in inflammation and inflammatory diseases

1 reference

12 December 2020

Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases

1 reference

12 December 2020

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

1 reference

12 December 2020

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

1 reference

12 December 2020

Transcriptional changes underlying the secretory activation phase of mammary gland development.

1 reference

12 December 2020

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

1 reference

12 December 2020

Regulation of JAK-STAT signalling in the immune system

1 reference

12 December 2020

10.1007/S10911-006-9014-4

Identifiers

DOI

1 reference

15 August 2017

1 reference