The significance of the cholinergic system in the brain during aging and in Alzheimer's disease (Q36622649)

15 August 2017

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title

The significance of the cholinergic system in the brain during aging and in Alzheimer's disease (English)

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15 August 2017

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R Schliebs

1

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PubMed ID

17039298

15 August 2017

T Arendt

series ordinal

2

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15 August 2017

13 October 2006

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Journal of Neural Transmission

15 August 2017

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15 August 2017

113

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15 August 2017

1625-1644

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15 August 2017

11

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https://scigraph.springernature.com/pub.10.1007/s00702-006-0579-2

15 August 2017

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Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence

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Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

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Necropsy evidence of central cholinergic deficits in senile dementia

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12 December 2020

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

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12 December 2020

Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability.

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12 December 2020

Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease.

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12 December 2020

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

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12 December 2020

Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study

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12 December 2020

DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites

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12 December 2020

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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12 December 2020

beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

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12 December 2020

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12 December 2020

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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12 December 2020

Selective loss of central cholinergic neurons in Alzheimer's disease

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12 December 2020

Decreased ratio of CSF acetylcholinesterase to butyrylcholinesterase activity in Alzheimer's disease.

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12 December 2020

Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion

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12 December 2020

Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep.

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12 December 2020

p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

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12 December 2020

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

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12 December 2020

Neuroreceptor changes in Alzheimer disease

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12 December 2020

Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence

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12 December 2020

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

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12 December 2020

The cholinergic neuronal phenotype in Alzheimer's disease

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12 December 2020

Advances in the pharmacotherapy of Alzheimer's disease

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12 December 2020

Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology

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12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

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12 December 2020

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

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12 December 2020

Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients.

1 reference

12 December 2020

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

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12 December 2020

Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor

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12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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12 December 2020

Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease

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12 December 2020

Acute stress facilitates long-lasting changes in cholinergic gene expression

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12 December 2020

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

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12 December 2020

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

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12 December 2020

Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons

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12 December 2020

Cholinergic 'blockade' as a model of the cognitive deficits in Alzheimer's disease

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12 December 2020

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

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12 December 2020

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

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12 December 2020

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12 December 2020

Amyloid beta(1-42) peptide alters the gating of human and mouse alpha-bungarotoxin-sensitive nicotinic receptors.

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12 December 2020

Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

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12 December 2020

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

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12 December 2020

Cholinesterase inhibitors: new roles and therapeutic alternatives

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12 December 2020

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12 December 2020

Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines

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12 December 2020

Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.

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12 December 2020

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12 December 2020

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

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12 December 2020

Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase.

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12 December 2020

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation

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12 December 2020

The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.

1 reference

12 December 2020

Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis

1 reference

12 December 2020

Regulated secretion of beta-amyloid precursor protein in rat brain

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

NGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer's disease.

1 reference

12 December 2020

Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells.

1 reference

12 December 2020

Basal forebrain neurons in the dementia of Parkinson disease

1 reference

12 December 2020

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

12 December 2020

Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue

1 reference

12 December 2020

Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats

1 reference

12 December 2020

Effects of long-term recovery from transient cerebral ischemia in rat brain: tissue levels of acetylcholine, monoamines, and their metabolites

1 reference

12 December 2020

Cholinergic expression by a neural stem cell line grafted to the adult medial septum/diagonal band complex

1 reference

12 December 2020

NGF promotes amyloid precursor protein secretion via muscarinic receptor activation

1 reference

12 December 2020

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

1 reference

12 December 2020

Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study.

1 reference

12 December 2020

Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities

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12 December 2020

NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis.

1 reference

12 December 2020

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

12 December 2020

Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins

1 reference

12 December 2020

The pharmacology of amyloid precursor protein processing.

1 reference

12 December 2020

Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol

1 reference

12 December 2020

Acetylcholinesterase and its inhibition in Alzheimer disease

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12 December 2020

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

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12 December 2020

Intraparenchymal NGF infusions rescue degenerating cholinergic neurons

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12 December 2020

Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats

1 reference

12 December 2020

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

1 reference

12 December 2020

Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications.

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12 December 2020

Cholinesterases and the Pathology of Alzheimer Disease

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12 December 2020

Donepezil therapy in clinical practice: a randomized crossover study

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12 December 2020

The pharmacology of donepezil: a new treatment of Alzheimer's disease

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

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12 December 2020

Activation of the intracerebral cholinergic nerve fibers originating in the basal forebrain increases regional cerebral blood flow in the rat's cortex and hippocampus

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12 December 2020

A primate model of Alzheimer's disease

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12 December 2020

Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of broca complex.

1 reference

12 December 2020

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

12 December 2020

Altered phosphofructokinase mRNA levels but unchanged isoenzyme pattern in brains from patients with Alzheimer's disease

1 reference

12 December 2020

NGF improves spatial memory in aged rodents as a function of age.

1 reference

12 December 2020

Spontaneous Aggregation and Cytotoxicity of the β-Amyloid Aβ1–40: A Kinetic Model

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12 December 2020

Attenuation of Abeta deposition in the entorhinal cortex of normal elderly individuals associated with tobacco smoking.

1 reference

12 December 2020

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

12 December 2020

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

1 reference

12 December 2020

A possible role for cholinergic neurons of the basal forebrain and pontomesencephalon in consciousness

1 reference

12 December 2020

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

12 December 2020

Evoked acetylcholine release by immortalized brain endothelial cells genetically modified to express choline acetyltransferase and/or the vesicular acetylcholine transporter

1 reference

12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

12 December 2020

Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity

1 reference

12 December 2020

1 reference

12 December 2020

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway

1 reference

12 December 2020

Development of laminar expression of the m2 muscarinic cholinergic receptor gene in rat visual cortex and the effect of monocular visual deprivation.

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12 December 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

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12 December 2020

Butyrylcholinesterase: impact on symptoms and progression of cognitive impairment

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction.

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12 December 2020

Neurotoxicity and oxidative damage of beta amyloid 1-42 versus beta amyloid 1-40 in the mouse cerebral cortex

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12 December 2020

Changes in brain cholinesterases in senile dementia of Alzheimer type.

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12 December 2020

Neurone loss in the nucleus basalis of Meynert in Creutzfeldt-Jakob disease

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12 December 2020

Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

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12 December 2020

The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase

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12 December 2020

Alzheimer disease: progress or profit?

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12 December 2020

Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease

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12 December 2020

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

12 December 2020

Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia.

1 reference

12 December 2020

Simulation of cortical cholinergic deficits--a novel experimental approach to study pathogenetic aspects of Alzheimer's disease

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12 December 2020

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

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12 December 2020

Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Abeta(1-40)

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12 December 2020

Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain

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12 December 2020

Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.

1 reference

12 December 2020

Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse

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12 December 2020

Functional neurochemistry of Alzheimer's disease

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12 December 2020

Cognitive functions of cortical acetylcholine: toward a unifying hypothesis

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12 December 2020

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection

1 reference

12 December 2020

Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

1 reference

12 December 2020

Neurobiology of butyrylcholinesterase.

1 reference

12 December 2020

Aluminum, NO, and nerve growth factor neurotoxicity in cholinergic neurons

1 reference

12 December 2020

Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion

1 reference

12 December 2020

Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies

1 reference

12 December 2020

Alzheimer's disease: interactions between cholinergic functions and beta-amyloid

1 reference

12 December 2020

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

12 December 2020

Cholinesterase inhibitors for Alzheimer's disease

1 reference

12 December 2020

Do cholinesterase inhibitors have disease-modifying effects in Alzheimer's disease?

1 reference

12 December 2020

Competitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer's disease.

1 reference

12 December 2020

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide

1 reference

12 December 2020

Neurochemical stimulation of the rat substantia innominata increases cerebral blood flow (but not glucose use) through the parallel activation of cholinergic and non-cholinergic pathways

1 reference

12 December 2020

Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein

1 reference

12 December 2020

Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology

1 reference

12 December 2020

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

1 reference

12 December 2020

Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists

1 reference

12 December 2020

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

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12 December 2020

Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.

1 reference

12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

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12 December 2020

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

1 reference

12 December 2020

P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease

1 reference

12 December 2020

Cholinesterase activity in the plaques, tangles and angiopathy of Alzheimer's disease does not emanate from amyloid.

1 reference

12 December 2020

Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs

1 reference

12 December 2020

Advances in the treatment of Alzheimer's disease: benefits of dual cholinesterase inhibition.

1 reference

12 December 2020

Molecular interactions of acetylcholinesterase with senile plaques.

1 reference

12 December 2020

Toxicity mediated by soluble oligomers of beta-amyloid(1-42) on cholinergic SN56.B5.G4 cells

1 reference

12 December 2020

Development of muscarinic cholinergic receptor binding in the visual system of monocularly deprived and dark reared rats.

1 reference

12 December 2020

Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons

1 reference

12 December 2020

Targeting acetylcholinesterase and butyrylcholinesterase in dementia

1 reference

12 December 2020

Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells

1 reference

12 December 2020

Acute and chronic effects of aluminum on acetyl-CoA and acetylcholine metabolism in differentiated and nondifferentiated SN56 cholinergic cells

1 reference

12 December 2020

Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.

1 reference

12 December 2020

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

1 reference

12 December 2020

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

1 reference

12 December 2020

Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains

1 reference

12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

12 December 2020

Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain

1 reference

12 December 2020

Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

1 reference

12 December 2020

Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess

1 reference

12 December 2020

Specificity of interneuronal connections

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12 December 2020

Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology

1 reference

12 December 2020

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

1 reference

12 December 2020

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

1 reference

12 December 2020

Observation of metastable Abeta amyloid protofibrils by atomic force microscopy

1 reference

12 December 2020

Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.

1 reference

12 December 2020

Beta-amyloid and cholinergic neurons

1 reference

12 December 2020

The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

1 reference

12 December 2020

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

1 reference

12 December 2020

Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism.

1 reference

12 December 2020

Cholinesterases: roles in the brain during health and disease.

1 reference

12 December 2020

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

1 reference

12 December 2020

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease

1 reference

12 December 2020

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

12 December 2020

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

12 December 2020

Advanced glycation endproducts in ageing and Alzheimer's disease

1 reference

12 December 2020

beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

1 reference

12 December 2020

beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons

1 reference

12 December 2020

A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme

1 reference

12 December 2020

Nerve growth factor signaling, neuroprotection, and neural repair

1 reference

12 December 2020

Correlation between Apolipoprotein-E polymorphism and Alzheimer's disease pathology.

1 reference

12 December 2020

In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses

1 reference

12 December 2020

192IGG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus

1 reference

12 December 2020

Cognitive sequelae of head injury: involvement of basal forebrain and associated structures

1 reference

12 December 2020

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

1 reference

12 December 2020

Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease.

1 reference

12 December 2020

Acetylcholine receptors and tau phosphorylation

1 reference

12 December 2020

Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice

1 reference

12 December 2020

Neurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells.

1 reference

12 December 2020

Nerve growth factor increases choline acetyltransferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons.

1 reference

12 December 2020

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

12 December 2020

The regulation of presenilin-1 by nerve growth factor

1 reference

12 December 2020

The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients.

1 reference

12 December 2020

Central cholinergic systems and cognition

1 reference

12 December 2020

Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro

1 reference

12 December 2020

Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion

1 reference

12 December 2020

Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model

1 reference

12 December 2020

Alzheimer plaques and cortical cholinergic innervation

1 reference

12 December 2020

Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation.

1 reference

12 December 2020

Conditionally immortal neuroepithelial stem cell grafts restore spatial learning in rats with lesions at the source of cholinergic forebrain projections cholinergic forebrain projections Conditionally immortal neuroepithelial stem cell grafts restor

1 reference

12 December 2020

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

1 reference

12 December 2020

Adverse effects associated with the use of donepezil in general practice in England.

1 reference

12 December 2020

Cholinergic-rich brain transplants reverse alcohol-induced memory deficits

1 reference

12 December 2020

Changes of activity and isozyme pattern of phosphofructokinase in the brains of patients with Alzheimer's disease.

1 reference

12 December 2020

Altered cholinergic metabolism in rat CNS following aluminum exposure: implications on learning performance.

1 reference

12 December 2020

Apolipoprotein E-deficient mice are not more susceptible to the biochemical and memory deficits induced by nucleus basalis lesion

1 reference

12 December 2020

Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman

1 reference

12 December 2020

Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease

1 reference

12 December 2020

Morphological substrates of mental dysfunction in Lewy body disease: an update.

1 reference

12 December 2020

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

1 reference

12 December 2020

The inhibitory and facilitatory actions of amyloid-beta peptides on nicotinic ACh receptors and AMPA receptors

1 reference

12 December 2020

Treatment of Alzheimer's disease with acetylcholinesterase inhibitors: bridging the gap between evidence and practice.

1 reference

12 December 2020

Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats

1 reference

12 December 2020

The cholinergic synapse and the site of memory

1 reference

12 December 2020

Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice

1 reference

12 December 2020

Amyloid beta neurotoxicity in the cholinergic but not in the serotonergic phenotype of RN46A cells

1 reference

12 December 2020

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

1 reference

12 December 2020

The role of nicotinic acetylcholine receptors in Alzheimer's disease

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

Cholinergic stimulation of AP-1 and NF kappa B transcription factors is differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis.

1 reference

12 December 2020

Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells

1 reference

12 December 2020

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

1 reference

12 December 2020

1 reference

12 December 2020

Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells.

1 reference

12 December 2020

DNA mutations associated with the human butyrylcholinesterase J-variant

1 reference

12 December 2020

Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease.

1 reference

12 December 2020

Butyrylcholinesterase in the life cycle of amyloid plaques.

1 reference

12 December 2020

Effect of early visual pattern deprivation on development and laminar distribution of cholinergic markers in rat visual cortex

1 reference

12 December 2020

beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes

1 reference

12 December 2020

The role of APOE polymorphisms in late-onset dementias.

1 reference

12 December 2020

WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties

1 reference

12 December 2020

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

1 reference

12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

12 December 2020

Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors.

1 reference

12 December 2020

Brain cholinergic vulnerability: relevance to behavior and disease

1 reference

12 December 2020

Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.

1 reference

12 December 2020

Self-assembly of Abeta(1-42) into globular neurotoxins.

1 reference

12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

12 December 2020

Contribution of acetylcholine to visual cortex plasticity

1 reference

12 December 2020

Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.

1 reference

12 December 2020

Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia

1 reference

12 December 2020

Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction

1 reference

12 December 2020

Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides.

1 reference

12 December 2020

Alzheimer's disease and NGF signaling

1 reference

12 December 2020

Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling

1 reference

12 December 2020

Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression.

1 reference

12 December 2020

NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease.

1 reference

12 December 2020

Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells

1 reference

12 December 2020

Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

1 reference

12 December 2020

Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus

1 reference

12 December 2020

Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein

1 reference

12 December 2020

Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor

1 reference

12 December 2020

In vivo consequences of M1-receptor activation by talsaclidine

1 reference

12 December 2020

Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion

1 reference

12 December 2020

Loss of nicotinic receptors induced by beta-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation.

1 reference

12 December 2020

Alzheimer plaques and cortical cholinergic innervation.

1 reference

12 December 2020

Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease

1 reference

12 December 2020

Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling

1 reference

12 December 2020

Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains.

1 reference

12 December 2020

Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging

1 reference

12 December 2020

Transplants of NGF-secreting fibroblasts restore stimulus-evoked activity in barrel cortex of basal-forebrain-lesioned rats

1 reference

12 December 2020

Neurochemical abnormalities in Alzheimer's disease and Parkinson's disease--a comparative review

1 reference

12 December 2020

Colocalization of cholinesterases with beta amyloid protein in aged and Alzheimer's brains.

1 reference

12 December 2020

Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway

1 reference

12 December 2020

Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors

1 reference

12 December 2020

Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease

1 reference

12 December 2020

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein.

1 reference

12 December 2020

10.1007/S00702-006-0579-2

Identifiers

DOI

1 reference

release_ouvrjd2idbajrmpeqxmit5nlqe

15 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ouvrjd2idbajrmpeqxmit5nlqe

24 November 2022

mapped directly with Wikidata item

PubMed ID

17039298

1 reference

PubMed ID

17039298