SHP-1 phosphatase activity counteracts increased T cell receptor affinity (Q36638160)

15 August 2017

SHP-1 phosphatase activity counteracts increased T cell receptor affinity (English)

1 reference

15 August 2017

6

Olivier Michielin

1 reference

15 August 2017

Michael Hebeisen

1

1 reference

15 August 2017

Lukas Baitsch

2

1 reference

15 August 2017

Danilo Presotto

3

1 reference

15 August 2017

Petra Baumgaertner

4

1 reference

15 August 2017

Pedro Romero

5

1 reference

15 August 2017

Daniel E Speiser

7

1 reference

15 August 2017

Nathalie Rufer

8

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15 August 2017

language of work or name

English

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publication date

8 February 2013

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Journal of Clinical Investigation

15 August 2017

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15 August 2017

123

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15 August 2017

3

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15 August 2017

1044-1056

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describes a project that uses

15 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3582132/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

30 September 2017

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30 September 2017

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B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity

30 September 2017

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Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness

30 September 2017

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30 September 2017

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30 September 2017

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Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

30 September 2017

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30 September 2017

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The role of the PD-1 pathway in autoimmunity and peripheral tolerance

30 September 2017

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Attenuated T cell responses to a high-potency ligand in vivo

30 September 2017

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SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells

30 September 2017

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Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

30 September 2017

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MM-GBSA binding free energy decomposition and T cell receptor engineering

30 September 2017

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Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

30 September 2017

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SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

30 September 2017

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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

30 September 2017

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

30 September 2017

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PD-1 and its ligands in tolerance and immunity

30 September 2017

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High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

30 September 2017

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miR-181a is an intrinsic modulator of T cell sensitivity and selection

30 September 2017

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30 September 2017

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Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity

30 September 2017

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A PD-1 polymorphism is associated with disease progression in multiple sclerosis.

30 September 2017

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T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

30 September 2017

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Dynamics of Cell Surface Molecules During T Cell Recognition

30 September 2017

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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

30 September 2017

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TCRs with high affinity for foreign pMHC show self-reactivity

30 September 2017

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A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

30 September 2017

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Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

30 September 2017

1 reference

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Complete but curtailed T-cell response to very low-affinity antigen

30 September 2017

1 reference

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The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

Comparison between computational alanine scanning and per-residue binding free energy decomposition for protein-protein association using MM-GBSA: application to the TCR-p-MHC complex.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3582132

20 September 2018

Identifiers

DOI

10.1172/JCI65325

1 reference

15 August 2017

1 reference

15 August 2017

PubMed publication ID

23391724

1 reference