The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production. (Q36647429)

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scientific article published on 7 January 2013

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English	The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.	scientific article published on 7 January 2013

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21 February 2020

The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production (English)

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21 February 2020

Niranjan Y Sardesai

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Kate E. Broderick

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Kate E Broderick

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21 February 2020

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Rashmi Jalah

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Margherita Rosati

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Brunda Ganneru

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Guy R Pilkington

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Antonio Valentin

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Viraj Kulkarni

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Cristina Bergamaschi

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Bhabadeb Chowdhury

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Gen-Mu Zhang

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Rachel Kelly Beach

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Candido Alicea

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George N Pavlakis

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Barbara K Felber

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21 February 2020

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21 February 2020

Journal of Biological Chemistry

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21 February 2020

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21 February 2020

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21 February 2020

6763-6776

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21 February 2020

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IL-12 family cytokines: immunological playmakers

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IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.

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30 September 2017

Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen

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Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo

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Gene therapy using IL 12 family members in infection, auto immunity, and cancer.

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Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans

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IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation

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30 September 2017

Immunotherapy of cancer by IL-12-based cytokine combinations

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30 September 2017

Interleukin-12: biological properties and clinical application

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30 September 2017

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

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30 September 2017

Gene therapy of cancer based on interleukin 12.

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DNA vaccines expressing different forms of simian immunodeficiency virus antigens decrease viremia upon SIVmac251 challenge

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Cytokines as clinical adjuvants: how far are we?

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30 September 2017

Intracellular localization of the p35 subunit of murine IL-12.

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IL-12: a promising adjuvant for cancer vaccination

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

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Biosynthesis and posttranslational regulation of human IL-12.

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Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

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Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation

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30 September 2017

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit

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Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.

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Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

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30 September 2017

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity

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Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein

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Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expression

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Rational design of a plasmid DNA vaccine capable of eliciting cell-mediated immune responses to multiple HIV antigens in mice

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Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trial

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Efficient systemic expression of bioactive IL-15 in mice upon delivery of optimized DNA expression plasmids

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10.1074/JBC.M112.436675

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21 February 2020

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21 February 2020

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21 February 2020

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