On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study. (Q36654358)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23324352%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study (English)

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22 February 2020

1

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22 February 2020

David P. Lane

4

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22 February 2020

Reidun Twarock

5

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22 February 2020

6

Leo S D Caves

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22 February 2020

author name string

Chandra S Verma

2

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22 February 2020

Thomas L Joseph

3

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22 February 2020

language of work or name

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16 January 2013

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22 February 2020

number of pages

11

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inferred from page(s)

published in

Cell Cycle

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22 February 2020

volume

12

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22 February 2020

issue

3

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22 February 2020

page(s)

394-404

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Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development

22 February 2020

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Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

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30 September 2017

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30 September 2017

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Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage

30 September 2017

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Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

30 September 2017

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Awakening guardian angels: drugging the p53 pathway

30 September 2017

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30 September 2017

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30 September 2017

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The importance of drug-target residence time.

30 September 2017

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The ups and downs of p53: understanding protein dynamics in single cells

30 September 2017

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

30 September 2017

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

30 September 2017

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Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

30 September 2017

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Residence time of receptor-ligand complexes and its effect on biological function

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

30 September 2017

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30 September 2017

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Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface.

30 September 2017

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30 September 2017

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30 September 2017

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Molecular mechanism of the interaction between MDM2 and p53.

30 September 2017

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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

30 September 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

30 September 2017

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30 September 2017

Surfing the p53 network

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MDM2--master regulator of the p53 tumor suppressor protein

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Brownian dynamics simulation of protein-protein diffusional encounter

30 September 2017

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MDMX: a novel p53-binding protein with some functional properties of MDM2

30 September 2017

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Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops

30 September 2017

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30 September 2017

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Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft.

28 June 2018

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Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin

28 June 2018

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Simulation of the diffusional association of barnase and barstar.

28 June 2018

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Regulation of p53 by Mdm2: fate is in the numbers

28 June 2018

1 reference

Length matters: C-terminal tails regulate Mdm2-MdmX complexes

21 January 2018

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On the protein-protein diffusional encounter complex.

21 January 2018

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Computational drug design accommodating receptor flexibility: the relaxed complex scheme

21 January 2018

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Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.

21 January 2018

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The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides.

21 January 2018

1 reference

Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition.

21 January 2018

1 reference

Targeting the conformational transitions of MDM2 and MDMX: insights into dissimilarities and similarities of p53 recognition.

21 January 2018

1 reference

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.

21 January 2018

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Protein-protein association: investigation of factors influencing association rates by Brownian dynamics simulations

21 January 2018

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The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

21 January 2018

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

Statistical thermodynamics. Taking a walk on a landscape

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12 December 2020

Role of electrostatic interactions in transient encounter complexes in protein-protein association investigated by paramagnetic relaxation enhancement

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12 December 2020

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

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12 December 2020

Identifiers

DOI

10.4161/CC.23511

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23324352%20AND%20SRC:MED&resulttype=core&format=json

release_anv2vykdbfcn7ppvjgv6g7bkbe

22 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/anv2vykdbfcn7ppvjgv6g7bkbe

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23324352%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

23324352

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23324352%20AND%20SRC:MED&resulttype=core&format=json