BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. (Q36692818)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23447565%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition (English)

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24 February 2020

2

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Elena Balestreire Hawryluk

24 February 2020

3

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24 February 2020

Dave S. Hoon

15

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24 February 2020

Jun S Song

17

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24 February 2020

Robert S. Langer, Jr.

10

object named as

Robert Langer

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18

David E Fisher

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24 February 2020

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Donald L Morton

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Jennifer A Wargo

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24 February 2020

5

Dennie Tompers Frederick

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24 February 2020

author name string

Rizwan Haq

1

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24 February 2020

Göran B Jönsson

4

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24 February 2020

Kevin McHenry

6

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24 February 2020

Dale Porter

7

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24 February 2020

Thanh-Nga Tran

8

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24 February 2020

Kevin T Love

9

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24 February 2020

Daniel G Anderson

11

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24 February 2020

Levi A Garraway

12

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24 February 2020

Lyn McDivitt Duncan

13

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24 February 2020

language of work or name

English

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publication date

27 February 2013

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Proceedings of the National Academy of Sciences of the United States of America

24 February 2020

published in

1 reference

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24 February 2020

volume

110

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issue

11

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24 February 2020

page(s)

4321-4326

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BCL2A1: the underdog in the BCL2 family

24 February 2020

cites work

1 reference

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

30 September 2017

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

30 September 2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

30 September 2017

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

30 September 2017

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Inhibition of Bfl-1 with N-aryl maleimides

30 September 2017

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

30 September 2017

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

30 September 2017

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Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma

30 September 2017

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

30 September 2017

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Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.

30 September 2017

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The landscape of somatic copy-number alteration across human cancers

30 September 2017

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

30 September 2017

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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

30 September 2017

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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

30 September 2017

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Oncogenic Braf induces melanocyte senescence and melanoma in mice

30 September 2017

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

30 September 2017

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Integrating BRAF/MEK inhibitors into combination therapy for melanoma.

30 September 2017

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Novel MITF targets identified using a two-step DNA microarray strategy

30 September 2017

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Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

30 September 2017

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

30 September 2017

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Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

30 September 2017

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30 September 2017

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Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

30 September 2017

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

30 September 2017

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Characterizing the cancer genome in lung adenocarcinoma

30 September 2017

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BRAF mutation predicts sensitivity to MEK inhibition

30 September 2017

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

30 September 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

30 September 2017

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

30 September 2017

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30 September 2017

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Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma

30 September 2017

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MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma

30 September 2017

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

30 September 2017

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Association of genomic imbalances with resistance to therapeutic drugs in human melanoma cell lines

30 September 2017

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alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome

30 September 2017

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Multiple gene duplication and expression of mouse bcl-2-related genes, A1.

30 September 2017

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Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells

30 September 2017

1 reference

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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

30 September 2017

1 reference

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Effects of Combined Thromboxane Synthetase Inhibition/Thromboxane Receptor Antagonism in Two Models of Sudden Cardiac Death in the Canine: Limited Role for Thromboxane

28 June 2018

1 reference

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

28 June 2018

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The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

5 September 2018

1 reference

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Novel genes associated with malignant melanoma but not benign melanocytic lesions

5 September 2018

1 reference

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Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1205575110

High-throughput oncogene mutation profiling in human cancer

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1205575110

21 January 2018

Identifiers

DOI

10.1073/PNAS.1205575110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23447565%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

0 references

1 reference

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24 February 2020

PubMed publication ID

23447565

1 reference