Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment (Q36698294)

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scientific article published on 31 January 2013

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English	Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment	scientific article published on 31 January 2013

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23 February 2020

Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment (English)

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Gregory D Gamble

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Beau Pontré

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Stephen Pickup

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Soon Y Choong

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Mingming Li

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Hong Xu

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Anthony R J Phillips

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Brett R Cowan

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31 January 2013

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Cardiovascular Diabetology

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Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice

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Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications

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Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis

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Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease

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The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat.

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Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy.

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Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

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The role of AGEs and AGE inhibitors in diabetic cardiovascular disease.

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30 September 2017

Left ventricular remodeling subsequent to reperfused myocardial infarction: evaluation of a rat model using cardiac magnetic resonance imaging

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30 September 2017

Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths

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30 September 2017

Magnetic resonance imaging analysis of cardiac cycle events in diabetic rats: the effect of angiotensin-converting enzyme inhibition

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Non-invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin-converting enzyme inhibition in diabetic rats

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30 September 2017

Role of AMP-activated protein kinase in mechanism of metformin action

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Function, structure, and mechanism of intracellular copper trafficking proteins

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Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc

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30 September 2017

Mechanism by which metformin reduces glucose production in type 2 diabetes

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30 September 2017

Glycochelates and the etiology of diabetic peripheral neuropathy

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30 September 2017

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

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30 September 2017

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Role of oxidative stress in development of complications in diabetes

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30 September 2017

Complex formation equilibria of Cu(II) and Zn(II) with triethylenetetramine and its mono- and di-acetyl metabolites

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28 June 2018

Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator

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28 June 2018

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

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28 June 2018

Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial

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28 June 2018

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28 June 2018

Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging

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28 June 2018

Mode of action of triethylenetetramine dihydrochloride on copper metabolism in Wilson's disease.

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28 June 2018

Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.

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5 September 2018

A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type 2 diabetic patients: a randomised placebo-controlled study

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A copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-beta activation in the kidneys of rats used as a model of diabetes.

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Development and validation of a rapid HPLC method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum

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5 September 2018

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5 September 2018

Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in

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Regeneration of the heart in diabetes by selective copper chelation

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5 September 2018

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5 September 2018

Quantitative gated PET for the assessment of left ventricular function in small animals

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5 September 2018

Effects of trientine, a metal chelator, on defective endothelium-dependent relaxation in the mesenteric vasculature of diabetic rats

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5 September 2018

Interactions of copper with glycated proteins: possible involvement in the etiology of diabetic neuropathy

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5 September 2018

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5 September 2018

Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride

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21 January 2018

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1 reference

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Response of isolated working hearts to fatty acids and carnitine palmitoyltransferase I inhibition during reduction of coronary flow in acutely and chronically diabetic rats

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https://pubmed.ncbi.nlm.nih.gov/23368770

12 December 2020

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Long-term treatment of Wilson's disease with triethylene tetramine dihydrochloride (trientine)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23368770

12 December 2020

based on heuristic

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Wilson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23368770

12 December 2020

based on heuristic

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Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23368770

12 December 2020

based on heuristic

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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23368770

12 December 2020

based on heuristic

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Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients

1 reference

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10.1186/1475-2840-12-28

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23 February 2020

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23 February 2020

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23 February 2020

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