Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease (Q37902643)

25 August 2017

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title

Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer's disease (English)

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25 August 2017

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Garth J S Cooper

1

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25 August 2017

1 July 2011

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25 August 2017

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25 August 2017

71

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25 August 2017

1281-1320

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25 August 2017

10

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https://scigraph.springernature.com/pub.10.2165/11591370-000000000-00000

25 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

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Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein

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21 January 2018

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The yeast Fre1p/Fre2p cupric reductases facilitate copper uptake and are regulated by the copper-modulated Mac1p activator

21 January 2018

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Identification of the copper regulon in Saccharomyces cerevisiae by DNA microarrays

21 January 2018

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Regulation of aortic CuZn-superoxide dismutase with copper. Caeruloplasmin and albumin re-activate and transfer copper to the enzyme in culture

21 January 2018

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Regulation of aortic CuZn-superoxide dismutase with copper. Effects in vivo

21 January 2018

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Retinal localization and copper-dependent relocalization of the Wilson and Menkes disease proteins.

21 January 2018

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Treatment of Wilson's disease with trientine (triethylene tetramine) dihydrochloride

21 January 2018

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21 January 2018

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21 January 2018

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Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults

21 January 2018

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21 January 2018

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Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator

21 January 2018

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Quantitative proteomic profiling identifies new renal targets of copper(II)-selective chelation in the reversal of diabetic nephropathy in rats.

21 January 2018

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Pharmacokinetics, pharmacodynamics, and metabolism of triethylenetetramine in healthy human participants: an open-label trial

21 January 2018

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Development and validation of a rapid HPLC method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum.

21 January 2018

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Determination of triethylenetetramine (TETA) and its metabolites in human plasma and urine by liquid chromatography-mass spectrometry (LC-MS).

21 January 2018

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21 January 2018

Polyamine homoeostasis

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Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator

21 January 2018

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Expert consensus document on arterial stiffness: methodological issues and clinical applications

21 January 2018

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Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?

21 January 2018

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Effect of long-term type 1 diabetes on renal sodium and water transporters in rats.

21 January 2018

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Roles of aquaporins in kidney revealed by transgenic mice

21 January 2018

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Molecular changes in proximal tubule function in diabetes mellitus

21 January 2018

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Acute copper sulphate poisoning: a case report and literature review

21 January 2018

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Transition metals and polyol pathway in the development of diabetic neuropathy in rats

21 January 2018

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Effect of the hydroxyl radical scavenger, dimethylthiourea, on peripheral nerve tissue perfusion, conduction velocity and nociception in experimental diabetes

21 January 2018

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Copper, Zinc, Manganese, and Magnesium Status and Complications of Diabetes Mellitus

21 January 2018

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The role of metal-catalyzed oxidation in the formation of advanced glycation end products: an in vitro study on collagen.

21 January 2018

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A population-based study of dementia in 85-year-olds.

21 January 2018

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Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

21 January 2018

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21 January 2018

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A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries

21 January 2018

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Coordination of copper(II) ions by the 11-20 and 11-28 fragments of human and mouse beta-amyloid peptide

21 January 2018

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

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Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide

21 January 2018

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Cu(II) interaction with amyloid-beta peptide: a review of neuroactive mechanisms in AD brains

21 January 2018

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Elevation of serum copper levels in Alzheimer's disease.

21 January 2018

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Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer's disease and is decreased by D-penicillamine

21 January 2018

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Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease.

21 January 2018

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APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein.

21 January 2018

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21 January 2018

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Amyloid beta peptide 1-42 highly correlates with capillary cerebral amyloid angiopathy and Alzheimer disease pathology.

21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid beta from the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

The galvanization of beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

The metallobiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Agents complexing copper as a therapeutic strategy for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Metal complexing agents as therapies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

The risks of free copper in the body and the development of useful anticopper drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

The curious case of clioquinol

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Impaired endothelium-dependent vasodilatation in women with previous gestational diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Effect of valsartan on the incidence of diabetes and cardiovascular events

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Direct detection and quantification of transition metal ions in human atherosclerotic plaques: evidence for the presence of elevated levels of iron and copper

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Acquired sideroblastic anaemia during treatment of Wilson's disease with triethylene tetramine dihydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Structure, properties, and function of a copper(I)-copper(II) complex of D-penicillamine: pentathallium(I) mu8-chloro-dodeca (D-penicillaminato)-octacuprate(I)hexacuprate(II) n-hydrate

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

Demyelination in Lambs Born of Ewes Maintained on High Intakes of Sulphate and Molybdate

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11591370-000000000-00000

SWAYBACK: A DEMYELINATING DISEASE OF LAMBS WITH AFFINITIES TO SCHILDER'S ENCEPHALITIS AND ITS PREVENTION BY COPPER.

21 January 2018

1 reference

12 December 2020

Crystal and molecular structure of bis(copper(II) D-penicillamine disulfide) nonahydrate, a derivative of copper(II) cystinate

1 reference

12 December 2020

Mechanisms of tolerance in the copper-loaded rat liver

1 reference

12 December 2020

Metabolism of administered triethylene tetramine dihydrochloride in humans

1 reference

12 December 2020

Manifestations of copper excess

1 reference

12 December 2020

An in vitro study on the role of metal catalyzed oxidation in glycation and crosslinking of collagen

1 reference

12 December 2020

Acute copper sulfate poisoning

1 reference

12 December 2020

Copper status of young men consuming a low-copper diet

1 reference

12 December 2020

Clinical manifestations of nutritional copper deficiency in infants and children

1 reference

12 December 2020

Cardiac hypertrophy in copper-deficient rats is owing to increased mitochondria

1 reference

12 December 2020

Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction

1 reference

12 December 2020

Role of copper in Indian childhood cirrhosis

1 reference

12 December 2020

Transition metals bind to glycated proteins forming redox active "glycochelates": implications for the pathogenesis of certain diabetic complications

1 reference

12 December 2020

Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men.

1 reference

12 December 2020

A delicate balance: homeostatic control of copper uptake and distribution

1 reference

12 December 2020

Illuminating the molecular basis of diabetic arteriopathy: A proteomic comparison of aortic tissue from diabetic and healthy rats

1 reference

12 December 2020

CARDIOVASCULAR STUDIES ON COPPER-DEFICIENT SWINE. IV. CONTENT AND SOLUBILITY OF THE AORTIC ELASTIN, COLLAGEN, AND HEXOSAMINE

1 reference

12 December 2020

Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

1 reference

12 December 2020

THE QUESTION OF COPPER DEFICIENCY IN MAN.

1 reference

12 December 2020

Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats

1 reference

12 December 2020

Proteomic analysis of the brain in Alzheimer’s disease: Molecular phenotype of a complex disease process

1 reference

12 December 2020

The Wilson disease gene: spectrum of mutations and their consequences.

1 reference

12 December 2020

Serum and urinary magnesium, calcium and copper levels in insulin-dependent diabetic women.

1 reference

12 December 2020

Clinical determinants of dememtia related to stroke

1 reference

12 December 2020

Copper biochemistry and molecular biology

1 reference

12 December 2020

Oxidative stress in Huntington's disease

1 reference

12 December 2020

Characterization of proteomic changes in cardiac mitochondria in streptozotocin-diabetic rats using iTRAQ™ isobaric tags

1 reference

12 December 2020

Copper in diseases and treatments, and copper-based anticancer strategies.

1 reference

12 December 2020

Cardiovascular studies on copper-deficient swine. II. Mechanical properties of the aorta

1 reference

12 December 2020

The 'mysterious' disease in Swedish moose. Concentrations of trace elements in liver and kidneys and clinical chemistry. Comparison with experimental molybdenosis and copper deficiency in the goat

1 reference

12 December 2020

Copper absorption, excretion, and retention by young men consuming low dietary copper determined by using the stable isotope 65Cu

1 reference

12 December 2020

Vascular factors and Alzheimer disease

1 reference

12 December 2020

Long-term treatment of Wilson's disease with triethylene tetramine dihydrochloride (trientine)

1 reference

12 December 2020

Wilson's Disease Treatment by Triethylene Tetramine Dihydrochloride (Trientine, 2HCI): Long-Term Observations

1 reference

12 December 2020

Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats

1 reference

12 December 2020

Mechanisms for protection against copper toxicity

1 reference

12 December 2020

Effects of combination lipid therapy in type 2 diabetes mellitus

1 reference

12 December 2020

Induction of increased collagen and elastin biosynthesis in copper-deficient pig aorta

1 reference

12 December 2020

Cardiac Wilson's disease

1 reference

12 December 2020

Transition metal-mediated glycoxidation accelerates cross-linking of beta-amyloid peptide

1 reference

12 December 2020

Drug development based on the metals hypothesis of Alzheimer's disease

1 reference

12 December 2020

Idiopathic copper toxicosis

1 reference

12 December 2020

In vivo evidence of hydroxyl radical formation after acute copper and ascorbic acid intake: electron spin resonance spin-trapping investigation

1 reference

12 December 2020

Swayback (enzootic ataxia) in Alberta lambs.

1 reference

12 December 2020

Vitamin E supplementation and cardiovascular events in high-risk patients

1 reference

12 December 2020

Protein Aging by Carboxymethylation of Lysines Generates Sites for Divalent Metal and Redox Active Copper Binding: Relevance to Diseases of Glycoxidative Stress

1 reference

12 December 2020

"Glycated hemoglobin," not "glycosylated" or "glucosylated"

1 reference

12 December 2020

Urinary copper excretion in type 2 diabetic patients with nephropathy

1 reference

12 December 2020

Indian childhood cirrhosis: several dilemmas resolved

1 reference

12 December 2020

Experimental copper and chromium deficiency and additional molybdenum supplementation in goats. II. Concentrations of trace and minor elements in liver, kidneys and ribs: haematology and clinical chemistry

1 reference

12 December 2020

Basic and clinical aspects of copper

1 reference

12 December 2020

Copper depletion and deficiency in the malnourished infant

1 reference

12 December 2020

Cerebral amyloid angiopathy in Lewy body disease

1 reference

12 December 2020

Endemic Tyrolean infantile cirrhosis: an ecogenetic disorder

1 reference

12 December 2020

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.

1 reference

12 December 2020

A randomized trial of copper therapy in rats with electrocardiographic abnormalities due to copper deficiency

1 reference

12 December 2020

Changes in the collagen of rat heart in copper-deficiency-induced cardiac hypertrophy

1 reference

12 December 2020

NaFe3+EDTA as a food fortificant: influence on zinc, calcium and copper metabolism in the rat

1 reference

12 December 2020

Copper deficiency complicating severe chronic intestinal malabsorption

1 reference

12 December 2020

Copper chelation in patients with Wilson's disease. A comparison of penicillamine and triethylene tetramine dihydrochloride

1 reference

12 December 2020

Experimental chronic copper toxicity in sheep. Histological and histochemical changes during the development of the lesions in the liver.

1 reference

12 December 2020

'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions

1 reference

12 December 2020

CARDIOVASCULAR STUDIES ON COPPER-DEFICIENT SWINE. VI. THE MUCOPOLYSACCHARIDE COMPOSITION OF AORTA AND CARTILAGE

1 reference

12 December 2020

Cellular mechanisms of toxicity and tolerance in the copper-loaded rat. II. Pathogenesis of copper toxicity in the liver

1 reference

12 December 2020

Neutropenia caused by copper deficiency: possible mechanisms of action.

1 reference

12 December 2020

Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide

1 reference

12 December 2020

1 reference

12 December 2020

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

1 reference

12 December 2020

Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications

1 reference

12 December 2020

Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu

1 reference

12 December 2020

Experimental chronic copper toxicity in sheep. Biochemical and haematological studies during the development of lesions in the liver

1 reference

12 December 2020

A Conspectus of Research on Copper Metabolism and Requirements of Man

1 reference

12 December 2020

Long-term high copper intake: effects on copper absorption, retention, and homeostasis in men.

1 reference

12 December 2020

Indications of copper deficiency in a subpopulation of Alaskan moose.

1 reference

12 December 2020

Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients

1 reference

12 December 2020

Copper deficiency and cardiovascular disease: role of peroxidation, glycation, and nitration

1 reference

12 December 2020

Physiological and metabolic characterization of a cardiomyopathy induced by chronic copper deficiency

1 reference

12 December 2020

Alterations in hypertrophic gene expression by dietary copper restriction in mouse heart

1 reference

12 December 2020

Triethylenetetramine and metabolites: levels in relation to copper and zinc excretion in urine of healthy volunteers and type 2 diabetic patients

1 reference

12 December 2020

Atrial thrombosis, abnormal electrocardiograms and sudden death in mice due to copper deficiency

1 reference

12 December 2020

Teratogenesis and low copper status resulting from D-penicillamine in rats

1 reference

12 December 2020

A syndrome of molybdenosis, copper deficiency, and type 2 diabetes in the moose population of south-west Sweden

1 reference

12 December 2020

Hepatic iron concentration combined with long-term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major

1 reference

12 December 2020

Identification of N epsilon- carboxymethyllysine as a degradation product of fructoselysine in glycated protein.

1 reference

12 December 2020

The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat.

1 reference

12 December 2020

Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.

1 reference

12 December 2020

Use and misuse of balance studies

1 reference

12 December 2020

Copper deficiency and copper toxicity in the rat

1 reference

12 December 2020

Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice

1 reference

12 December 2020

10.2165/11591370-000000000-00000

Identifiers

DOI

1 reference

PubMed ID

21770477

Dimensions Publication ID

25 August 2017

0 references

1 reference

PubMed ID

21770477