Is YKL-40 a new therapeutic target in cancer? (Q36709555)

15 August 2017

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title

Is YKL-40 a new therapeutic target in cancer? (English)

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15 August 2017

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Julia S Johansen

1

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15 August 2017

Benny Vittrup Jensen

series ordinal

2

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15 August 2017

Anne Roslind

series ordinal

3

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15 August 2017

Paul A Price

series ordinal

4

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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Expert Opinion on Therapeutic Targets

15 August 2017

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15 August 2017

11

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15 August 2017

2

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15 August 2017

219-234

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Serum YKL-40, a new prognostic biomarker in cancer patients?

15 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum YKL-40 and colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Early detection and prognosis of ovarian cancer using serum YKL-40.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Crystal structure of a novel regulatory 40-kDa mammary gland protein (MGP-40) secreted during involution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Purification of guinea pig YKL40 and modulation of its secretion by cultured articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Characterization and biological roles of oviduct-specific, oestrogen-dependent glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Identification of a novel acidic mammalian chitinase distinct from chitotriosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Structural and sequence-based classification of glycoside hydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Gp38k, a protein synthesized by vascular smooth muscle cells, stimulates directional migration of human umbilical vein endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Gene expression in papillary thyroid carcinoma reveals highly consistent profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

HC gp-39 gene is upregulated in glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Inflammation and cancer: back to Virchow?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

21 January 2018

Inflammation and cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Mechanisms of disease: Inflammation and the origins of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Tumor-associated macrophages: the double-edged sword in cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Mechanism of glucocorticoid-induced depletion of human CD14+CD16+ monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Regulation of YKL-40 production by human articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The synovial proteome: analysis of fibroblast-like synoviocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

The role of fibroblasts in tumor behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Putting tumours in context

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Tumor reversion: Correction of malignant behavior by microenvironmental cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Cells expressing the DG42 gene from early Xenopus embryos synthesize hyaluronan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Does DG42 synthesize hyaluronan or chitin?: A controversy about oligosaccharides in vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Hyaluronan: from extracellular glue to pericellular cue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum YKL-40 levels in healthy children and adults. Comparison with serum and synovial fluid levels of YKL-40 in patients with osteoarthritis or trauma of the knee joint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Raised human cartilage glycoprotein-39 plasma levels in patients with rheumatoid arthritis and other inflammatory conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Circulating YKL-40 levels during human endotoxaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

YKL-40 levels in the cerebrospinal fluid and serum of patients with aneurysmal subarachnoid hemorrhage: preliminary results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Effect of antiviral therapy on markers of fibrogenesis in patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Prediction of hepatic fibrosis in HIV/HCV co-infected patients using serum fibrosis markers: the SHASTA index

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Acute-phase proteins and other systemic responses to inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

What does minor elevation of C-reactive protein signify?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

Clusterin plays an important role in hepatocellular carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.2.219

10.1517/14728222.11.2.219

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference