Amyloid-β induces hepatic insulin resistance in vivo via JAK2. (Q36720621)

15 August 2017

Amyloid-β induces hepatic insulin resistance in vivo via JAK2. (English)

1 reference

15 August 2017

1 reference

1 reference

Yi Zhang

1

1 reference

15 August 2017

Ben Zhou

2

1 reference

15 August 2017

Bo Deng

3

1 reference

15 August 2017

Fang Zhang

4

1 reference

15 August 2017

Jingxia Wu

5

1 reference

15 August 2017

Yuangao Wang

6

1 reference

15 August 2017

Yingying Le

7

1 reference

15 August 2017

Qiwei Zhai

8

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15 August 2017

language of work or name

English

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publication date

6 December 2012

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15 August 2017

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15 August 2017

62

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15 August 2017

4

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15 August 2017

1159-1166

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

15 August 2017

start time

28 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Amyloid-β induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway

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Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance

30 September 2017

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Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

30 September 2017

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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

30 September 2017

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Type 2 diabetes across generations: from pathophysiology to prevention and management

30 September 2017

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Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

30 September 2017

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Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses

30 September 2017

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How does diabetes accelerate Alzheimer disease pathology?

30 September 2017

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Alzheimer's disease: strategies for disease modification

30 September 2017

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Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

30 September 2017

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30 September 2017

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Common features between diabetes mellitus and Alzheimer's disease

30 September 2017

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Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

30 September 2017

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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

30 September 2017

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Disordered lipid metabolism and the pathogenesis of insulin resistance

30 September 2017

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Diabetes and suppressors of cytokine signaling proteins

30 September 2017

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

30 September 2017

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Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

30 September 2017

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Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance

30 September 2017

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

30 September 2017

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

30 September 2017

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Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

30 September 2017

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

30 September 2017

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Putting the brakes on insulin signaling.

30 September 2017

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Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

30 September 2017

https://pubmed.ncbi.nlm.nih.gov/23223021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Correct homeostasis model assessment (HOMA) evaluation uses the computer program

1 reference

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JAK2/STAT2/STAT3 are required for myogenic differentiation

30 September 2017

1 reference

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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

28 June 2018

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Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Glucose and memory in mild senile dementia of the Alzheimer type

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Amyloid precursor protein expression is upregulated in adipocytes in obesity.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Plasma Abeta42 correlates positively with increased body fat in healthy individuals.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Plasma levels of amyloid beta-protein 42 are increased in women with mild cognitive impairment.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Increased risk of type 2 diabetes in Alzheimer disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609589

Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23223021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Amyloid beta oligomers induce impairment of neuronal insulin receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23223021

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB12-0670

1 reference

15 August 2017

1 reference

15 August 2017

1 reference