Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis (Q36731403)

15 August 2017

Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis (English)

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15 August 2017

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Andrew Johnston

1

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15 August 2017

Xianying Xing

2

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15 August 2017

William R Swindell

3

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15 August 2017

James Kochkodan

4

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15 August 2017

Marybeth Riblett

5

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15 August 2017

Rajan P Nair

6

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15 August 2017

Philip E Stuart

7

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15 August 2017

Jun Ding

8

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15 August 2017

John J Voorhees

9

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15 August 2017

James T Elder

10

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15 August 2017

Johann E Gudjonsson

11

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15 August 2017

31 January 2013

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15 August 2017

Human Molecular Genetics

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15 August 2017

22

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15 August 2017

9

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15 August 2017

1807-1815

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describes a project that uses

15 August 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/3613166

inferred from PubMed Central ID database lookup

cites work

Psoriasis and other complex trait dermatoses: from Loci to functional pathways

1 reference

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Cutting edge: A critical functional role for IL-23 in psoriasis.

30 September 2017

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Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models

30 September 2017

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Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

30 September 2017

1 reference

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Molecular dissection of psoriasis: integrating genetics and biology

30 September 2017

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The IL-23/Th17 axis in the immunopathogenesis of psoriasis

30 September 2017

1 reference

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Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice

30 September 2017

1 reference

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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways

30 September 2017

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From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited

30 September 2017

1 reference

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Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis

30 September 2017

1 reference

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Lack of evidence for activation of the hedgehog pathway in psoriasis

30 September 2017

1 reference

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

30 September 2017

1 reference

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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

30 September 2017

1 reference

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Polymorphisms of the IL12B and IL23R genes are associated with psoriasis

30 September 2017

1 reference

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

30 September 2017

1 reference

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30 September 2017

Psoriasis: epidemiology

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Phenotypic and functional features of human Th17 cells

30 September 2017

1 reference

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A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

30 September 2017

1 reference

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

30 September 2017

1 reference

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Transforming growth factor-beta induces development of the T(H)17 lineage

30 September 2017

1 reference

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

30 September 2017

1 reference

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

30 September 2017

1 reference

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

30 September 2017

1 reference

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Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

30 September 2017

1 reference

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

30 September 2017

1 reference

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The lineage decisions of helper T cells

30 September 2017

1 reference

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

30 September 2017

1 reference

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

30 September 2017

1 reference

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Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions

30 September 2017

1 reference

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The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiat

30 September 2017

1 reference

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Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

30 September 2017

1 reference

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Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells

30 September 2017

1 reference

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A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin

28 June 2018

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The transient nature of the Th17 phenotype.

5 September 2018

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IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

5 September 2018

1 reference

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OrderedList--a bioconductor package for detecting similarity in ordered gene lists.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613166

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3613166

The Cytokine Network in Lesional and Lesion-Free Psoriatic Skin Is Characterized by a T-Helper Type 1 Cell-Mediated Response

5 September 2018

1 reference

12 December 2020

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele

1 reference

12 December 2020

T cells involved in psoriasis vulgaris belong to the Th1 subset

1 reference

12 December 2020

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

1 reference

12 December 2020

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

1 reference

12 December 2020

A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion

1 reference

12 December 2020

Taq-I polymorphism in 3′UTR of the IL-12B and association with IL-12p40 production from human PBMC

1 reference

12 December 2020

Retinoic Acid Receptor Gene Expression in Human Skin

1 reference

12 December 2020

The effect of Goeckerman therapy on interferon in serum and suction blister fluid from patients with psoriasis

1 reference

12 December 2020

IL-12 and IL-10 polymorphisms and their effects on cytokine production

1 reference

12 December 2020

Interferon in suction blister fluid from psoriatic lesions

1 reference

12 December 2020

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/HMG/DDT034

1 reference

15 August 2017

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15 August 2017

PubMed publication ID

23376980

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