The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network (Q36743530)

16 August 2017

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title

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network (English)

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Gene Ontology release 2020-05-02

16 August 2017

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1

Kieran Harvey

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16 August 2017

Nicolas Tapon

2

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language of work or name

English

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publication date

1 March 2007

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16 August 2017

published in

Nature Reviews Cancer

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16 August 2017

volume

7

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16 August 2017

issue

3

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16 August 2017

page(s)

182-191

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https://scigraph.springernature.com/pub.10.1038/nrc2070

16 August 2017

exact match

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cites work

Size control in animal development

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

31 March 2020

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

31 March 2020

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

31 March 2020

1 reference

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

31 March 2020

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

31 March 2020

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

31 March 2020

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

31 March 2020

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

31 March 2020

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

31 March 2020

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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

31 March 2020

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Delineation of a Fat tumor suppressor pathway

31 March 2020

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

31 March 2020

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Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

31 March 2020

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The Drosophila RASSF homolog antagonizes the hippo pathway

31 March 2020

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

31 March 2020

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

31 March 2020

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The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

31 March 2020

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Merlin and ERM proteins: unappreciated roles in cancer development?

31 March 2020

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ERM proteins and merlin: integrators at the cell cortex

31 March 2020

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The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

31 March 2020

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CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila

31 March 2020

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Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila

31 March 2020

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Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

31 March 2020

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Identification of Nore1 as a potential Ras effector

31 March 2020

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Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

31 March 2020

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RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

31 March 2020

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The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung

31 March 2020

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RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.

31 March 2020

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A novel interaction motif, SARAH, connects three classes of tumor suppressor

31 March 2020

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NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis

31 March 2020

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The Ste20 group kinases as regulators of MAP kinase cascades

31 March 2020

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Men and sin: what's the difference?

31 March 2020

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Mitotic-exit control as an evolved complex system

31 March 2020

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SIN and the art of splitting the fission yeast cell

31 March 2020

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

31 March 2020

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

31 March 2020

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

31 March 2020

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

31 March 2020

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

31 March 2020

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

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Role of the Ras-association domain family 1 tumor suppressor gene in human cancers

31 March 2020

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Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Genetic and epigenetic alteration of theNF2gene in sporadic meningiomas

31 March 2020

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Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2.

31 March 2020

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

31 March 2020

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A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors

31 March 2020

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

31 March 2020

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Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.

31 March 2020

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Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization.

31 March 2020

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A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

31 March 2020

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Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

31 March 2020

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Multiple microalterations detected at high frequency in oral cancer

31 March 2020

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Methylation of the RASSF1A gene in human cancers

31 March 2020

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Identification of a novel Ras-regulated proapoptotic pathway

31 March 2020

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Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

31 March 2020

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Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

31 March 2020

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Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.

31 March 2020

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GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.

31 March 2020

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Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases

31 March 2020

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

31 March 2020

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

31 March 2020

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Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila

31 March 2020

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The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

31 March 2020

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Growth regulation: a beginning for the hippo pathway

31 March 2020

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Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

31 March 2020

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Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis

31 March 2020

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Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis

31 March 2020

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Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.

31 March 2020

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The bantam microRNA is a target of the hippo tumor-suppressor pathway

31 March 2020

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The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

31 March 2020

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

31 March 2020

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Cleavage and secretion is not required for Four-jointed function in Drosophila patterning.

31 March 2020

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Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

31 March 2020

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Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.

31 March 2020

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Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila

31 March 2020

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The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

31 March 2020

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The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance

31 March 2020

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Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

31 March 2020

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Drosophila p53 binds a damage response element at the reaper locus

31 March 2020

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

31 March 2020

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A protein interaction map of Drosophila melanogaster

31 March 2020

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Direct and long-range action of a DPP morphogen gradient.

31 March 2020

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Ras1 promotes cellular growth in the Drosophila wing

31 March 2020

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

31 March 2020

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Cyclin E in normal and neoplastic cell cycles

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2070

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16 August 2017

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