The molecular culprits underlying precocious mammary gland involution (Q36745470)

16 August 2017

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title

The molecular culprits underlying precocious mammary gland involution (English)

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16 August 2017

3

Jane E Visvader

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16 August 2017

Kate D Sutherland

1

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PubMed ID

17323120

16 August 2017

Geoffrey J Lindeman

series ordinal

2

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16 August 2017

1 March 2007

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Journal of Mammary Gland Biology and Neoplasia

16 August 2017

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16 August 2017

12

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16 August 2017

1

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16 August 2017

15-23

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https://scigraph.springernature.com/pub.10.1007/s10911-007-9034-8

16 August 2017

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cites work

The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements

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Crossref

https://api.crossref.org/works/10.1007%2FS10911-007-9034-8

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

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12 December 2020

The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

1 reference

12 December 2020

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

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12 December 2020

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.

1 reference

12 December 2020

Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice

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12 December 2020

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

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12 December 2020

Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

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12 December 2020

PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

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12 December 2020

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements

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12 December 2020

Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells

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12 December 2020

Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia

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12 December 2020

STAT3 is required for the gp130-mediated full activation of the c-myc gene

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12 December 2020

Hormonal control of insulin-like growth factor-binding protein-5 production in the involuting mammary gland of the rat

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12 December 2020

Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene

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12 December 2020

Milk accumulation triggers apoptosis of mammary epithelial cells

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12 December 2020

Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution

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12 December 2020

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.

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12 December 2020

Developmental stage determines the effects of MYC in the mammary epithelium

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12 December 2020

Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

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12 December 2020

Wnt signaling and cancer

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12 December 2020

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12 December 2020

SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

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12 December 2020

Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways

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12 December 2020

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

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12 December 2020

Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice.

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12 December 2020

ECM degrading proteases and tissue remodelling in the mammary gland

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12 December 2020

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution

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12 December 2020

Differential activation of STATs 3 and 5 during mammary gland development.

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12 December 2020

Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells

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12 December 2020

Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution

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12 December 2020

Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.

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12 December 2020

Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells.

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12 December 2020

Wnt signaling: is the party in the nucleus?

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12 December 2020

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

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12 December 2020

Role of DDC-4/sFRP-4, a secreted frizzled-related protein, at the onset of apoptosis in mammary involution.

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12 December 2020

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

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12 December 2020

Requirement for IGF-I in epidermal growth factor-mediated cell cycle progression of mammary epithelial cells

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12 December 2020

Perturbation of beta1-integrin function alters the development of murine mammary gland

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12 December 2020

Matrix metalloproteinases: effectors of development and normal physiology

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12 December 2020

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

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12 December 2020

Ways of dying: multiple pathways to apoptosis.

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12 December 2020

Mitogenic properties of insulin-like growth factors I and II, insulin-like growth factor binding protein-3 and epidermal growth factor on human breast epithelial cells in primary culture

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12 December 2020

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

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12 December 2020

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

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12 December 2020

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

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12 December 2020

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

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12 December 2020

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

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12 December 2020

Accelerated apoptosis in the Timp-3-deficient mammary gland

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12 December 2020

Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3

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12 December 2020

SOCS3 regulates the plasticity of gp130 signaling

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12 December 2020

Mammary gland involution is delayed by activated Akt in transgenic mice.

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12 December 2020

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

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12 December 2020

Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

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12 December 2020

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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12 December 2020

Insulin-like growth factor binding proteins: IGF-dependent and -independent effects in the mammary gland

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12 December 2020

Wnt-cadherin connections in normal and neoplastic mammary epithelium.

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12 December 2020

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

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12 December 2020

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.

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12 December 2020

A novel role for IRF-1 as a suppressor of apoptosis

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12 December 2020

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland

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12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

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12 December 2020

E-cadherin is a survival factor for the lactating mouse mammary gland

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12 December 2020

A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

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12 December 2020

Lactation status influences expression of CCAAT/enhancer binding protein isoform mRNA in the mouse mammary gland

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12 December 2020

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

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12 December 2020

Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin

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12 December 2020

C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution

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12 December 2020

SOCS3 negatively regulates IL-6 signaling in vivo

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12 December 2020

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.

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12 December 2020

10.1007/S10911-007-9034-8

Identifiers

DOI

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16 August 2017

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PubMed ID

17323120