Lessons from high-throughput protein crystallization screening: 10 years of practical experience. (Q36798187)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646073%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Lessons from high-throughput protein crystallization screening: 10 years of practical experience (English)

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2 February 2020

2

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2 February 2020

author name string

Joseph R Luft

series ordinal

1

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2 February 2020

George T Detitta

series ordinal

3

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2 February 2020

language of work or name

English

0 references

publication date

22 March 2011

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Expert Opinion on Drug Discovery

2 February 2020

published in

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2 February 2020

volume

6

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2 February 2020

issue

5

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2 February 2020

page(s)

465-480

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Small angle X-ray scattering as a complementary tool for high-throughput structural studies

2 February 2020

cites work

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Femtosecond X-ray protein nanocrystallography

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Challenges and opportunities for new protein crystallization strategies in structure-based drug design

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New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization

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The minimum crystal size needed for a complete diffraction data set.

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Protein crystallization analysis on the World Community Grid

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The 2.1 Å crystal structure of an acyl-CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl-binding pocket for small branched acyl substrates

29 September 2017

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Insight into the substrate length restriction of M32 carboxypeptidases: characterization of two distinct subfamilies

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29 September 2017

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Operator-assisted harvesting of protein crystals using a universal micromanipulation robot

29 September 2017

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Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1

29 September 2017

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Active-Site Gating Regulates Substrate Selectivity in a Chymotrypsin-Like Serine Protease

29 September 2017

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

29 September 2017

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Molecular mimicry of SUMO promotes DNA repair

29 September 2017

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Different Poses for Ligand and Chaperone in Inhibitor-Bound Hsp90 and GRP94: Implications for Paralog-Specific Drug Design

29 September 2017

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Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins

29 September 2017

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The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme

29 September 2017

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Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1

29 September 2017

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Structure of NS1A effector domain from the influenza A/Udorn/72 virus

29 September 2017

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Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data.

29 September 2017

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Structural Characterization of the Hemophore HasAp from Pseudomonas aeruginosa : NMR Spectroscopy Reveals Protein−Protein Interactions between Holo-HasAp and Hemoglobin † , ‡

29 September 2017

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Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis

29 September 2017

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The application and use of chemical space mapping to interpret crystallization screening results

29 September 2017

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Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin

29 September 2017

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29 September 2017

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Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase † ‡

29 September 2017

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Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system

29 September 2017

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Crystal structure of the pyocyanin biosynthetic protein PhzS

29 September 2017

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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

29 September 2017

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Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica

29 September 2017

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In situ proteolysis for protein crystallization and structure determination

29 September 2017

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Automated robotic harvesting of protein crystals-addressing a critical bottleneck or instrumentation overkill?

29 September 2017

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Biochemical and structural characterization of Pseudomonas aeruginosa Bfd and FPR: ferredoxin NADP+ reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions

29 September 2017

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MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone

29 September 2017

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Structure and Function of the Escherichia coli Protein YmgB: A Protein Critical for Biofilm Formation and Acid-resistance

29 September 2017

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Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid

29 September 2017

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Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Crystal structure of Homo sapiens kynureninase

29 September 2017

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Distinct effector-binding sites enable synergistic transcriptional activation by BenM, a LysR-type regulator

29 September 2017

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High resolution crystal structures of the p120 RasGAP SH3 domain

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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A droplet-based, composite PDMS/glass capillary microfluidic system for evaluating protein crystallization conditions by microbatch and vapor-diffusion methods with on-chip X-ray diffraction

29 September 2017

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The promise of macromolecular crystallization in microfluidic chips

29 September 2017

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29 September 2017

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The genesis of high-throughput structure-based drug discovery using protein crystallography

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The Biological Macromolecule Crystallization Database and NASA Protein Crystal Growth Archive

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SAmBA: an interactive software for optimizing the design of biological macromolecules crystallization experiments.

29 September 2017

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Crystallization and preliminary X-ray studies of the N-domain of the Wilson disease associated protein

29 September 2017

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27 June 2018

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Establishing a training set through the visual analysis of crystallization trials. Part I: approximately 150,000 images.

27 June 2018

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27 June 2018

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5 September 2018

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Searching for silver bullets: an alternative strategy for crystallizing macromolecules

5 September 2018

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5 September 2018

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Screening and optimization strategies for macromolecular crystal growth

5 September 2018

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Development of a technology for automation and miniaturization of protein crystallization.

5 September 2018

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5 September 2018

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Automated diffraction image analysis and spot searching for high-throughput crystal screening

21 January 2018

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A supersaturation wave of protein crystallization

21 January 2018

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A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments

21 January 2018

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12 December 2020

Non-ideality of aqueous solutions of polyethylene glycol: consequences for its use as a macromolecular crystallizing agent in vapor-diffusion experiments

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12 December 2020

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels

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12 December 2020

[5] Response surface methods for optimizing and improving reproducibility of crystal growth

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12 December 2020

Automated protein crystallization and a new crystal form of a subtilisin:eglin complex

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12 December 2020

10.1517/17460441.2011.566857

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646073%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646073%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22646073

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646073%20AND%20SRC:MED&resulttype=core&format=json