Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251. (Q36808324)

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scientific article published on 3 February 2009

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English	Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251.	scientific article published on 3 February 2009

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20 January 2020

Co-immunization with IL-15 enhances cellular immune responses induced by a vif-deleted simian immunodeficiency virus proviral DNA vaccine and confers partial protection against vaginal challenge with SIVmac251 (English)

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Simian immunodeficiency virus

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Barbara L Shacklett

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Francois Villinger

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Francois Villinger

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Ellen E Sparger

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Robert A Dubie

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Saipiroon Maksaereekul

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Donna Lemongello

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20 January 2020

Sequential priming with simian immunodeficiency virus (SIV) DNA vaccines, with or without encoded cytokines, and a replicating adenovirus-SIV recombinant followed by protein boosting does not control a pathogenic SIVmac251 mucosal challenge

1 reference

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Vaccination of rhesus macaques with a vif-deleted simian immunodeficiency virus proviral DNA vaccine

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Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid

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IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques

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Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

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Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

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